Apparatus and method for iontophoretic transfer

• US 5,088,978 A
• Filed: 01/26/1990
• Issued: 02/18/1992
• Est. Priority Date: 01/26/1990
• Status: Expired due to Fees

• Current Assignee: Gensia Pharmaceuticals, Inc. (Teva Pharmaceutical Industries Limited)
• Original Assignee: Gensia Pharmaceuticals, Inc. (Teva Pharmaceutical Industries Limited)
• Inventors: Hillman, Robert S., Pawelchak, John M.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Rose, Sharon
• Application Number:
  US07/471,296
• Time in Patent Office: 753 Days
• Field of Search: 604/20, 128/639, 128/802, 128/803
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0448 Drug reservoir

Abstract

An apparatus and method for iontophoretic transdermal delivery of exercise simulating agents includes an electrode having disposed therein a drug reservoir comprising a viscosity-control agent comprising an aqueous sol with an antioxidant, a preservative, a chelator and a buffer. A silver/silver chloride conducive element is preferably situated in the electrode adjacent the drug reservoir to conduct an electric charge across the reservoir.

Claims

1. A transdermal iontophoretic drug delivery system for delivering an exercise simulating agent comprising:

an electrode including

a metallic conductive element, and a gel reservoir, the gel reservoir being disposed adjacent to the metallic conductive element, and

a gel disposed in the gel reservoir including a catecholamine analog as an exercise stimulating agent, a viscosity-control agent comprising hydroxypropyl methylcellulose dispersed to form an aqueous sol with an antioxidant, a preservative, a chelator and a buffer.

2. The delivery system set forth in claim 1 wherein said viscosity control agent is METHOCEL®

(hydroxypropyl methylcellulose) E10M.

3. The delivery system set forth in claim 1 wherein said viscosity control agent is METHOCEL®

(hydroxypropyl methylcellulose) E10M, said antioxidant is sodium metabisulfite, said preservative is a mixture of methyl and propyl parabens, said chelator is disodium salt of EDTA, and said buffer is citric acid/citrate.

4. The delivery system set forth in claim 1 comprising 4-10% (w/v) hydroxypropyl methylcellulose, 0.1-10% (w/v) sodium metabisulfite, 0.001-0.05% (w/v) disodium salt of EDTA, 0.001-0.05M citric acid/citrate, 0.10-0.20% (w/v) parabens which comprises a mixture of methyl and 0.02-0.04% (w/v) propyl.

5. The transdermal iontophoretic drug delivery system of claim 1 wherein the metallic conductive element includes silver.

6. The transdermal iontophoretic drug delivery system of claim 5 wherein the metallic conductive element is silver/silver chloride.

7. A transdermal iontophoretic drug delivery system for delivering GP-2-121-3 comprising:

an electrode including a metallic conductive element, and

a reservoir adjacent to the metallic conductive element,

a gel disposed in the reservoir including GP-2-121-3, a viscosity control agent comprising 4-10% (w/v) hydroxypropyl methylcellulose, 0.1-10% (w/v) sodium metabisulfite, 0.0001-0.05% (w/v) disodium salt of EDTA, 0.005-0.05M citric acid/citrate, 0.10-0.20% (w/v) parabens which comprises a mixture of methyl and 0.02-0.04% (w/v) propyl.

8. The delivery system set forth in claim 7 further including a silver/silver chloride conductive element disposed in adjacent engagement with said reservoir.

9. The delivery system set forth in claim 8 further including an indifferent electrode comprising a reservoir having disposed therein 4-10% (w/v) hydroxypropyl methylcellulose, 0.1-0.5% sodium chloride, 0.10-0.20% (w/v) parabens, 0.10-0.20% (w/v) Sodium H₂ PO₄ and 80-95% (w/v) water.

10. A method for iontophoretically delivering a catecholamine amino isopropanol exercise simulating agent comprising applying to a patient'"'"'s skin a first electrode comprising a reservoir containing a substance to be iontophoretically delivered, said reservoir further comprising a viscosity control agent comprising 4-10% (w/v) hydroxypropyl methylcellulose, 0.1-10% (w/v) sodium metabisulfite, 0.001-0.05% (w/v) disodium salt of EDTA, 0.005-0.05M citric acid/citrate, 0.10-0.20% (w/v) parabens which comprises a mixture of methyl and 0.02-0.04% (w/v) propyl, said method further comprising securing a second electrode to the patient a short distance from said first electrode, said second electrode comprising a gel reservoir having disposed therein 4-10% (w/v) hydroxypropyl methylcellulose, 0.1-0.5% sodium chloride, 0.10-0.20% (w/v) parabens, 0.10-0.20% (w/v) Sodium H₂ PO₄ and 80-95% (w/v) water, and applying an electrical potential across said electrodes.