Fertility prediction by use of clomiphene challenge test
First Claim
1. A method for predicting the fertility or infertility of a human female patient which comprises administering clomiphene to said patient during the period of days 2-9 of said patient'"'"'s menstrual cycle, measuring the follicle stimulating hormone response level of said patient during the period of days 9-11 of said patient'"'"'s menstrual cycle, and comparing said response level to normal response levels, wherein a response level significantly greater than normal response levels is predictive of infertility and a response level within normal response levels is predictive of fertility.
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Abstract
The fertility of females, especially human females can be predicted by use of a clomiphene challenge test. The test is based upon comparison of follicle stimulating hormone and/or luteinizing hormone levels in urine or blood samples at two points in the menstrual cycle. The first test is performed on days 2-3 of the cycle. Clomiphene, and most preferably clomiphene in the form of clomiphene citrate, in a dosage of about 100 mg/day, is then administered, preferably on days 5-9. The second test is conducted on days 9-10. The test results are most conveniently compared by colorimetric methods involving monoclonal antibody reactions with follicle stimulating hormone and/or luteininizing hormone.
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Citations
21 Claims
- 1. A method for predicting the fertility or infertility of a human female patient which comprises administering clomiphene to said patient during the period of days 2-9 of said patient'"'"'s menstrual cycle, measuring the follicle stimulating hormone response level of said patient during the period of days 9-11 of said patient'"'"'s menstrual cycle, and comparing said response level to normal response levels, wherein a response level significantly greater than normal response levels is predictive of infertility and a response level within normal response levels is predictive of fertility.
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9. A method of predicting the fertility or infertility of a human female patient which comprises:
- determining a baseline level for follicle stimulating hormone in the period of days 2-3 of said patient'"'"'s menstrual cycle;
administering clomiphene to said patient during the period of days 2-9 of said patient'"'"'s menstrual cycle;
determining a response level of follicle stimulating hormone in the period of days 9-11 of said patient'"'"'s menstrual cycle; andcomparing said response level to said baseline level, wherein a response level significantly elevated over said baseline level is predictive of infertility. - View Dependent Claims (10, 11, 12, 13, 14)
- determining a baseline level for follicle stimulating hormone in the period of days 2-3 of said patient'"'"'s menstrual cycle;
- 15. A method of predicting the fertility or infertility of a human female patient which comprises administering clomiphene to said patient during the period of days 2-9 of said patient'"'"'s menstrual cycle, measuring the luteinizing hormone response level of said patient during the period of days 9-11 of said patient'"'"'s menstrual cycle, and comparing said response level to normal response levels, wherein a response level significantly greater than normal response levels is predictive of infertility.
- 17. A method of predicting the fertility or infertility of a human female patient which comprises administering clomiphene to said patient during the period of days 2-9 of said patient'"'"'s menstrual cycle, measuring the follicle stimulating hormone response level and the luteinizing hormone response level of said patient during the period of days 9-11 of said patient'"'"'s menstrual cycle, and comparing said response levels, wherein a follicle stimulating hormone response level greater than the luteinizing hormone response level is predictive of infertility.
Specification