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Tris-maleimido compounds as intermediates in trifunctional antibody synthesis

  • US 5,091,542 A
  • Filed: 03/09/1990
  • Issued: 02/25/1992
  • Est. Priority Date: 03/09/1990
  • Status: Expired due to Fees
First Claim
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1. A compound of the formula:

  • ##STR22## wherein X is ##STR23## wherein k=1 or 0;

    wherein Z is ##STR24## wherein s=1 or 0;

    wherein n=1;

    wherein q=1 or 0;

    wherein Y is ##STR25## wherein Y'"'"' is ##STR26## wherein p or m may be the same or different and are integers ranging from 0 to 20 with the provisos that when n=1, p and m are each an integer that is at least 1 and the sum of p and m is an integer ranging from 2 to 20;

    wherein R1 is straight or branched chain lower alkyl having from 1 to 6 carbon atoms or lower alkoxy having from 1-6 carbon atoms; and

    wherein R2 is hydrogen phenyl, --COOH, or straight or branched chain lower alkyl having from 1-6 carbon atoms optionally monosubstituted by --NH2, --OH, or --COOH.

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