Steroid eluting cuff electrode for peripheral nerve stimulation

• US 5,092,332 A
• Filed: 02/22/1990
• Issued: 03/03/1992
• Est. Priority Date: 02/22/1990
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Johnson, Gary, Gates, James, Lee, Philip, Stokes, Kenneth
• Primary Examiner(s): Cohen, Lee S.
• Application Number:
  US07/483,455
• Time in Patent Office: 740 Days
• Field of Search: 128/784-786, 128/419 P, 128/419 C, 128/642, 128/50
• US Class Current: 600/377
• CPC Class Codes: A61N 1/0556 Cuff electrodes

Abstract

An improved electrode for establishing electrical contact with a nerve of a patient. This electrical contact may be used to sense neural activity on the nerve or to artificially stimulate it to perform various medical treatments. The electrode has an outer cuff of an insulating material which is sutured around the nerve to be contacted. A drug impregnated layer of material is positioned inside of the outer cuff. This material is a polymeric matrix which permits the drug to leach out at a predetermined rate. The drug is a steroid such as dexamethasone sodium phosphate. The actual electrical contact is produced by metallic foil which is positioned on the surface of the drug impregnated layer of material which is located inside of the cuff. An insulated lead electrically couples the metallic foil to an electronic circuit located remote from the nerve. The leaching out of the drug serves to control irritation, swelling, and impedance of the nerve/electrode interface.

Claims

1. A nerve electrode comprising:

a. substrate means for coupling to said nerve;

b. means attached to said substrate means for chronically chemically treating irritation of said nerve;

c. conductive electrode means attached to said chronically chemically treating means for electrically coupling to said nerve; and

d. insulated electrical lead coupled to said conductive electrode means to couple said conductive electrode means to a remote electronic circuit.

2. A nerve electrode according to claim 1 wherein said substrate means is a flexible insulator.

3. A nerve electrode according to claim 2 wherein said chronically chemically treating means covers one surface of said substrate means.

4. A nerve electrode according to claim 3 wherein said chronically chemically treating means is a polymeric matrix containing a steroid drug.

5. A nerve electrode according to claim 4 wherein said steroid drug is dexamethasone sodium phosphate.

6. A nerve electrode according to claim 5 wherein said polymeric matrix further comprises silastic medical adhesive.

7. A nerve electrode according to claim 6 wherein said substrate means has a length of 3/8 inch and a width of 1/4 inch.

8. A method of treating chronic irritation of nerve tissue coupled to a neurological electrode comprising:

a. attaching a material containing an elutable steroid drug to said neurological electrode and in contact with said nerve tissue; and

b. permitting said steroid drug to leach out of said material and into said nerve tissue.