Method for promoting soft connective tissue growth and repair in mammals

• US 5,092,883 A
• Filed: 12/13/1990
• Issued: 03/03/1992
• Est. Priority Date: 12/28/1988
• Status: Expired due to Term

• Current Assignee: Barry L. Eppley, Marilyn D. Krukowski, Philip A. Osdoby
• Original Assignee: Barry L. Eppley, Marilyn D. Krukowski, Philip A. Osdoby
• Inventors: Eppley, Barry L., Osdoby, Philip A., Krukowski, Marilyn D.
• Primary Examiner(s): Isabella, David J.
• Assistant Examiner(s): BRITTINGHAM, DEBRA
• Application Number:
  US07/626,844
• Time in Patent Office: 446 Days
• Field of Search: 606/76, 606/77, 623/11, 623/12, 623/16, 623/66
• US Class Current: 424/422
• CPC Class Codes: A61L 27/20 Polysaccharides
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: C08L 5/02 Dextran; Derivatives thereof
• CPC Class Codes: Y10S 623/917 Collagen
• CPC Class Codes: Y10S 623/919 Bone

Abstract

A material with chemically induced surface charges is employed to foster formation of mammalian hard and soft connective tissues. The material may be in the form of beads such as ion exchange resins. Bead materials with a negative surface charge stimulate formation of hard tissue within long bones and foster bony repair of defects in parietal bones and in mandibular rami. Beads with positively charged surfaces engender formation of large quantities of soft dense connective tissue when implanted into defects in the cranium or when used as an onlay on the nasal bone surface. The use of such beads or other charged biodegradable materials and the use of other surface charged materials with different physical configurations provides significant improvement in hard and soft connective tissue repair, augmentation and replacement in medical fields such as orthopaedic and maxillofacial surgery.

Claims

1. A method for promoting soft connective tissue growth and repair in sites of tissue defects in living mammals which comprises applying an effective quantity of charged material with a deliberately produced chemically induced effective surface charge to said sites, the tissue being soft connective tissue and the tissue defects being caused by at least one of trauma, malignancy and malformation in said soft connective tissue and said charged material being applied to said site and said material being an ion exchange material having a positive charge, said effective quantity being sufficient to promote said growth and repair.

2. The method of claim 1 in which the material is biodegradable.

3. The method of claim 1 in which said material is applied in the form of small discrete spherical beads.

6. The method of claim 1 in which said material is directly applied to said soft connective tissue sites.

7. The method of claim 1 in which a fabric, mesh or sheet, containing said charge material is fashioned into an appropriate shape and size, and said fabric, mesh or sheet is placed onto said site.

8. The method of claim 1 in which the material serves as a vehicle for the introduction of growth factors into soft connective tissue sites for correction of defects.

9. The method of claim 1 in which the material serves as a vehicle for the introduction of growth factors and other mitogenic proteins into soft connective tissue sites for correction of defects.

10. The method of claim 1 in which the material is an integral component of alloplastic material that may be used for at least one of soft connective tissue fixation, stabilization, reconstruction and replacement.

11. The method of claim 1 in which the material is an integral component of alloplastic material that may be used for at least one of soft connective tissue ingrowth into prothesis for fixation, stabilization, reconstruction and replacement.

13. The method of claim 1 in which said material is added to the site of a wound for wound repair.

14. The method of claim 1 in which said material is added to the site by a fat graft.

15. The method of claim 14 in which said material serves as a vehicle for the introduction of growth factor or other mitogenic protein.

16. The method of claim 15 in which the growth factor is a basic fibroblast growth factor.

4. A method for promoting soft connective tissue growth and repair in site of tissue defects in living mammals which comprises applying an effective quantity of charged material with a deliberately produced chemically induced effective surface charge to said sites, said effective quantity being sufficient to promote said growth and repair, said tissue site being soft connective tissue and the tissue defects being caused by at least one of trauma, malignancy and malformation in said soft connective tissue and said charged material being applied to said site, said charged material having a positive charge and said charged material being applied in the form of small discrete spherical beads, said beads being a biodegradable ion exchange material and comprised of a dextran matrix having functional groups.

5. The method of claim 4 in which the functional groups comprise diethylamine.

12. A method for promoting soft connective tissue growth and repair in sites of tissue defects in living mammals which comprises applying an effective quantity of charged material with a deliberately produced chemically induced effective surface charge to said sites, said effective quantity being sufficient to promote said growth and repair, said tissue site being soft connective tissue and the tissue defects being caused by at least one of trauma, malignancy and malformation in said soft connective tissue and said charge material being applied to said site, said charged material having a positive charge and said charged material being applied in the form of small discrete spherical beads, said beads being an ion exchange material and comprised of a dextran matrix having functional groups.