Polyethylene glycol substituted phenyl glyoxals
First Claim
1. A polyethylene glycol derivative of the formula ##STR7## wherein R represents a lower alkyl and n represents a positive integer which renders the average molecular weight of the polyethylene glycol moiety about 1,000-12,000.
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Accused Products
Abstract
A polyethylene glycol derivative of the formula ##STR1## wherein R represents a lower alkyl and n represents an optional positive integer which renders the average molecular weight of the polyethylene glycol moiety about 1,000 to 12,000, a peptide modified by said polyethylene glycol derivative and a method for production thereof.
The polyethylene glycol derivative (I) is capable of modifying the guanidino groups in peptides. The peptides modified by the polyethylene glycol derivative (I) are extremely stable, are considerably delayed in biological clearance (i.e. the durability is extended) and exhibit their physiological activities effectively over the long period.
25 Citations
2 Claims
- 1. A polyethylene glycol derivative of the formula ##STR7## wherein R represents a lower alkyl and n represents a positive integer which renders the average molecular weight of the polyethylene glycol moiety about 1,000-12,000.
Specification
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- Resources
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Current AssigneeSumitomo Pharmaceuticals Company Limited (Sumitomo Chemical Company Limited)
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Original AssigneeSumitomo Pharmaceuticals Company Limited (Sumitomo Chemical Company Limited)
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InventorsMaeda, Hiroo, Ono, Keiichi, Kai, Yoshiyuki, Sano, Akihiko
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Primary Examiner(s)Moezie, F. T.
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Assistant Examiner(s)ROZYCKI, ANDREW
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Application NumberUS07/347,902Time in Patent Office1,033 DaysField of Search530/402, 530/406, 568/308, 568/335, 568/337, 526/313, 526/316US Class Current568/337CPC Class CodesC07K 1/064 for omega-amino or -guanidi...C07K 1/1077 by covalent attachment of r...C08G 65/323 containing halogensC08G 65/329 with organic compoundsC08G 65/3346 having sulfur bound to carb...
