Method and system for upstream occlusion detection

• US 5,096,385 A
• Filed: 11/08/1989
• Issued: 03/17/1992
• Est. Priority Date: 11/08/1989
• Status: Expired due to Term

• Current Assignee: Carefusion 303 Incorporated (Becton, Dickinson & Co)
• Original Assignee: Ivax Corporation (Teva Pharmaceutical Industries, Ltd.)
• Inventors: Butterfield, Robert, Smith, Oliver J., Georgi, Heinz W.
• Primary Examiner(s): Smith, Leonard E.
• Application Number:
  US07/433,627
• Time in Patent Office: 860 Days
• Field of Search: 417/12, 417/18, 417/53, 417/63, 417/474, 604/67, 604/153
• US Class Current: 417/18
• CPC Class Codes: A61M 2005/16872 Upstream occlusion sensors
• CPC Class Codes: A61M 5/14228 with linear peristaltic action, i.e. comprising at least three pressurising members or a helical member
• CPC Class Codes: A61M 5/16859 Evaluation of pressure response, e.g. to an applied pulse

Abstract

The method and system for detecting occlusion in a fluid line upstream of a pump concerns a fluid pump with a pump cycle in which the upstream pressure of the fluid line is communicated to the downstream portion of the fluid line. A pressure sensor located downstream of the pump is capable of measuring a relatively large negative-going pressure in the fluid line. A signal is generated to indicate occlusion based upon detection of negative-going pressure.

Claims

1. A method for detecting an occlusion in a fluid line upstream of a pump adapted to cause fluid to flow from an upstream portion to a downstream portion of said fluid line, said pump having a duty cycle including a transition period in which fluid pressure is communicated from said upstream portion to said downstream portion of said fluid line, the steps of said method comprising:

monitoring fluid pressure in said fluid line downstream of said pump during said transition period to detect the occurrence of a negative-going pressure waveform;

determining the power content of said detected negative-going pressure waveform over a range of frequencies;

comparing said power content with a predetermined power threshold; and

generating an occlusion signal when said waveform power content exceeds said predetermined power threshold.

2. The method of claim 1, wherein said power content is determined from the root mean square of said negative-going pressure waveform over said range of frequencies.

3. The method of claim 1, wherein said range of frequencies is from about 5 to about 30 Hz.

4. The method of claim 1, wherein said power content is determined from a pressure-time integral of the negative-going pressure waveform with respect to a beginning baseline pressure.

5. A method for detecting an occlusion in a fluid line upstream of a pump adapted to cause fluid to flow from an upstream portion to a downstream portion of said fluid line, said pump having a cycle with a period during which fluid pressure is communicated from said upstream portion to said downstream portion of said fluid line, the steps of said method comprising:

monitoring fluid pressure in said fluid line downstream of said pump during the period of said pump cycle during which fluid pressure is communicated from said upstream portion to said downstream portion to detect the occurrence of negative-going pressure in said fluid line; and

generating a signal indicating an occlusion when negative-going pressure is detected.

6. The method of claim 5, wherein said signal indicating an occlusion is generated only when said negative-going pressure falls below a predetermined negative pressure threshold.

7. The method of claim 6, wherein said predetermined negative pressure threshold is -30 mmHg.

8. The method of claim 5, wherein said step of monitoring fluid pressure further comprises sampling said fluid pressure at a plurality of times to provide a plurality of pressure samples, determining the difference between two samples which are a predetermined time interval apart, and generating said occlusion signal when said difference is greater than a predetermined difference threshold.

9. The method of claim 8, wherein said difference threshold is about 60 mmHg for a predetermined time interval of about 10 ms.

10. The method of claim 5, further comprising the step of determining the slope and amplitude of said negative-going pressure, and generating said occlusion signal only when said slope is greater than a predetermined slope threshold and said negative-going pressure falls below a predetermined pressure threshold.

11. The method of claim 5, wherein said pump is a peristaltic pump operating on a pumping segment of said fluid line and having a plurality of occluding fingers which move fluid in a peristaltic manner.

12. The method of claim 11, wherein said fluid pressure is monitored during a detection window in each said period of said pump cycle when the most downstream peristaltic finger of said pump opens said pumping segment to the fluid line downstream of said pump.

13. The method of claim 5, further comprising the step of detecting an artifact condition by monitoring fluid pressure in said fluid line prior to said pump cycle period during which fluid pressure is communicated from said upstream portion to said downstream portion, comparing said monitored pressure to a predetermined artifact minimum pressure threshold and generating an artifact signal when said monitored pressure falls below said artifact threshold.

14. The method of claim 13, wherein the step of detecting said artifact condition comprises determining the amplitude and slope of said fluid pressure, and generating said artifact signal when either said amplitude falls below an artifact minimum pressure threshold, or said slope exceeds an artifact slope threshold.

15. The method of claim 13, further comprising the step of monitoring fluid pressure during said period in an interval of non-flow prior to communication of said fluid pressure from said upstream portion to said downstream portion of said fluid line, determining a parameter of the variability of fluid pressure during said interval, and generating an artifact signal when said parameter of variability of fluid pressure exceeds a predefined threshold.

16. The method of claim 5, further comprising the step of detecting an artifact condition by monitoring fluid pressure in said fluid line prior to said pump cycle period during which fluid pressure is communicated from said upstream portion to said downstream portion, comparing said monitored pressure to a predetermined artifact minimum pressure threshold and inhibiting the generation of said occlusion signal when said monitored pressure falls below said artifact threshold.

17. The method of claim 5, wherein said negative-going pressure has a waveform comprising a range of frequencies, and further comprising the steps of determining the power content of said negative-going pressure detected over a range of frequencies, comparing said power content with a power content threshold, and generating said occlusion signal when said power content exceeds said power content threshold.

18. The method of claim 17, wherein said power content is determined from the root mean square of said negative-going pressure waveform over said range of frequencies.

19. The method of claim 17, wherein said range of frequencies is from about 5 to about 30 Hz.

20. The method of claim 17, wherein said power content is determined from a pressure-time integral of the negative-going pressure waveform with respect to a beginning baseline pressure.

21. A system for detecting an occlusion in a portion of a fluid line upstream of a pump, the pump being adapted to cause fluid to flow from the upstream portion to a downstream portion of said fluid line, said pump having a cycle with a period during which fluid pressure is communicated from said upstream to said downstream portion of said fluid line, the system comprising:

means for monitoring fluid pressure in said fluid line downstream of said pump during the period of said pump cycle during which fluid is communicated from said upstream portion to said downstream portion to detect the occurrence of negative-going pressure in said fluid line; and

means for generating a signal indicating an occlusion in said upstream portion of the fluid line when negative-going pressure is detected by said means for monitoring.

22. The system of claim 21, wherein said signal indicating an occlusion is generated only when said negative-going pressure falls below a predetermined negative pressure threshold.

23. The system of claim 21, wherein said means for monitoring fluid pressure further comprises means for sampling said fluid pressure at a plurality of times to provide a plurality of pressure samples, means for determining the difference between two samples which are a predetermined time interval apart, and means for generating said occlusion signal when said difference is greater than a predetermined difference threshold.

24. The system of claim 21, further comprising means for determining the slope and amplitude of said negative pressure, and means for generating said occlusion signal only when said slope is greater than a predetermined slope threshold and said negative-going pressure falls below a predetermined pressure threshold.

25. The system of claim 21, wherein said pump is a peristaltic pump operating on a pumping segment of said fluid line and having a plurality of fingers which move fluid in a peristaltic manner.

26. The system of claim 25, wherein said fluid pressure is monitored during a detection window in each said period of said pump cycle when the most downstream peristaltic finger of said pump opens said pumping segment to the fluid line downstream of said pump.

27. In an intravenous fluid administration system including a fluid line, and a pump adapted to cause fluid to flow from an upstream portion to a downstream portion of said fluid line, said pump having a duty cycle with a cyclical flow transition period during which fluid pressure is communicated downstream to induce a negative pressure transient downstream of said pump when an occlusion exists in said fluid line upstream of said pump, an upstream occlusion detection system comprising the combination of:

a pressure detector for measuring fluid pressure in said fluid line at a location downstream of said pump;

means for monitoring said fluid pressure in said fluid line downstream of said pump during said flow transition period to detect the occurrence of each negative pressure transient; and

means for generating an occlusion signal indicating an occlusion condition upstream of said pump when a said negative pressure transient is detected.

28. The combination of claim 27, further comprising means for determining the amplitude of each negative-going pressure transient, and said occlusion signal generating means being operative to generate said occlusion signal only when said amplitude falls below a minimum pressure threshold.

29. The combination claim 27, wherein said means for monitoring said fluid pressure further comprises means for providing a plurality of pressure samples, means for determining the difference between two samples a predetermined time interval apart for at least one pair of said pressure samples, and said means for generating said occlusion signal being operative to generate said occlusion signal when said difference is greater than a predetermined difference threshold.

30. The combination of claim 27, further comprising means for determining the slope and amplitude of each said negative pressure transient, and said means for generating said occlusion signal being operative to generate said occlusion signal only when said slope is greater than a predetermined slope threshold and said amplitude falls below a predetermined minimum pressure threshold.

31. The combination of claim 27, further comprising means for detecting an artifact condition by monitoring fluid pressure in said fluid line prior to said pump cycle period during which fluid pressure is communicated from said upstream portion to said downstream portion, means for comparing said monitored pressure to a predetermined artifact minimum pressure threshold and means for generating an artifact signal when said monitored pressure falls below said artifact threshold.

32. The combination of claim 27, further comprising means for detecting an artifact condition by monitoring fluid pressure in said fluid line prior to said pump cycle period during which fluid pressure is communicated from said upstream portion to said downstream portion, means for comparing said monitored pressure to a predetermined artifact minimum pressure threshold and means for inhibiting the generation of said occlusion signal when said monitored pressure falls below said artifact threshold.

33. The combination of claim 27, wherein each negative pressure transient has a waveform over a range of frequencies, and further comprising means for determining power content of each said negative pressure transient detected over a range of frequencies, means for comparing said power content with an power threshold, and said means for generating said occlusion signal being operative to generate said occlusion signal only when said power content exceeds said power threshold.

34. In a system for detecting an occlusion in a fluid line upstream of a pump wherein the pump operates on said fluid line to cause fluid to flow from an upstream portion to a downstream portion of said fluid line, said pump having a cycle with a non-flow transition period during which fluid pressure is communicated from said upstream portion to said downstream portion of said fluid line, the combination comprising:

means for monitoring fluid pressure in said fluid line downstream of said pump during said non-flow transition period to detect the occurrence of a negative-going pressure transient; and

means for determining power content over a range of frequencies of each said negative-going pressure transient detected by said means for monitoring, comparing said power content with a power threshold, and generating an occlusion signal when said power content exceeds said power threshold.