Fiber optic chemical sensors incorporating electrostatic coupling

• US 5,096,671 A
• Filed: 03/15/1989
• Issued: 03/17/1992
• Est. Priority Date: 03/15/1989
• Status: Expired due to Term

• Current Assignee: Cordis Corporation (Cardinal Health, Inc.)
• Original Assignee: Cordis Corporation (Cardinal Health, Inc.)
• Inventors: Pinchuk, Leonard, Kane, James A.
• Primary Examiner(s): Johnston, Jill A.
• Application Number:
  US07/324,239
• Time in Patent Office: 1,098 Days
• Field of Search: 422/82.06, 422/82.07, 422/82.11, 436/68, 350/96.29, 356/39, 356/412, 128/634, 385/12, 427/163, 427/164, 427/165, 427/169, 427/443.2, 436/166
• US Class Current: 422/82.07
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: G01N 2021/6434 Optrodes
• CPC Class Codes: G01N 2021/772 Tip coated light guide
• CPC Class Codes: G01N 2021/775 Indicator and selective membrane
• CPC Class Codes: G01N 21/7703 using reagent-clad optical fibres or optical waveguides using measurement of total internal reflection or attenuated total reflection G01N21/552; optical fibres or waveguides per se G02B
• CPC Class Codes: G01N 21/80 Indicating pH value

Abstract

Fiber optic chemical sensors and materials suitable for use in making same are provided. A charged hydrogel matrix membrane is suitable for affixing to the distal end portion and the like of an optical fiber waveguide, which charged hydrogel matrix has dispersed therewithin an oppositely charged ion exchange resin powder, which ion exchange powder has a colorimetric indicator component electrostatically coupled thereto, which colorimetric indicator component has the same charge as the charged hydrogel.

Claims

1. A fiber optic chemical sensor for monitoring at least one parameter of a fluid, comprising:

an optical fiber waveguide having a distal end portion;

a chemical sensor at said distal end portion said chemical sensor having an anionic hydrogel matrix membrane adhered to said distal end portion of the optical fiber waveguide;

cationic ion exchange resin material dispersed within said anionic matrix membrane; and

an anionic colorimetric indicator component electrostatically coupled to said cationic ion exchange resin material.

2. The chemical sensor according to claim 1, wherein said ion exchange resin material comprises ion exchange resin beads ground to resin powder.

3. The chemical sensor according to claim 1, wherein said ion exchange resin material is a powder of micron-sized ion exchange resin particles.

4. The chemical sensor according to claim 1, wherein said ion exchange resin material is water insoluble.

5. The chemical sensor according to claim 1, wherein said anionic colorimetric indicator component is irreversibly bound to said ion exchange resin material.

6. The chemical sensor according to claim 1, wherein said hydrogel matrix membrane is generally soluble in a solvent within which said ion exchange resin material is dispersible, and said hydrogel matrix membrane has a refractive index that allows the colorimetric indicator to be visible through said optical fiber waveguide.

7. The chemical sensor according to claim 1, wherein said hydrogel matrix membrane is a polyurethane urea having anionic moieties.

8. A fiber optic chemical sensor for monitoring at least one parameter of a fluid, comprising:

an optical fiber waveguide having a distal end portion;

a chemical sensor at said distal end portion, said chemical sensor having a cationic hydrogel matrix membrane adhered to said distal end portion of the optical fiber waveguide;

anionic ion exchange resin material dispersed within said cationic matrix membrane; and

a cationic indicator component electrostatically coupled to said anionic ion exchange resin material.

9. The chemical sensor according to claim 8, wherein said ion exchange resin material comprises ion exchange resin beads ground to resin powder.

10. The chemical sensor according to claim 8, wherein said ion exchange resin material is water insoluble.

11. The chemical sensor according to claim 8, wherein said anionic colorimetric indicator component is irreversibly bound to said ion exchange resin material.

12. The chemical sensor according to claim 8, wherein said cationic hydrogel matrix membrane is a hydrophilic photogelling matrix polymer.

13. A fiber optic chemical sensor for monitoring at least one parameter of a fluid, comprising:

an optical fiber waveguide having a distal end portion;

a chemical sensor at said distal end portion, said chemical sensor having a charged hydrogel matrix membrane adhered to said distal end portion of the optical fiber waveguide;

ion exchange resin material dispersed within said charged hydrogel matrix membrane, said ion exchange resin material having a charge opposite to that of said charged hydrogel matrix membrane; and

a colorimetric indicator component electrostatically coupled to said ion exchange resin material, said colorimetric indicator component having the same charge as said charged hydrogel matrix material.

14. The chemical sensor according to claim 13, wherein said ion exchange resin material comprises ion exchange resin beads ground to resin powder.

15. The chemical sensor according to claim 13, wherein said ion exchange resin material is water insoluble.

16. The chemical sensor according to claim 13, wherein said anionic colorimetric indicator component is substantially irreversibly bound to said ion exchange resin material.

17. The chemical sensor according to claim 13, wherein said charged hydrogel matrix membrane is a hydrogel material selected from the group consisting of polyurethane ureas having charged moieties, copolymers of hydroxyalkyl methacrylates and tertiary aminoalkyl methacrylates, and copolymers of sulfoalkyl methacrylate salts and hydroxyalkyl methacrylate.

18. A process for making a fiber optic chemical sensor for monitoring at least one parameter of a fluid, comprising:

providing a charged ion exchange resin material in powdered form;

electrostatically coupling by mixing said powdered ion exchange resin material with a solution of a colorimetric indicator component having a charge opposite to the charge of the charged ion exchange resin powder in order to thereby form a stained ion exchange material which is said ion exchange resin powder electrostatically bound to said colorimetric indicator;

mixing a charged hydrogen component with said stained ion exchange material, said charged hydrogel component having a charge the same as that of said colorimetric indicator component and opposite to that of the ion exchange material in order to thereby provide an optrode composition of said stained ion exchange material dispersed in said charged hydrogel component; and

affixing said optrode composition to a distal portion of an optical fiber waveguide.

19. The process according to claim 18, wherein said electrostatic coupling step includes placing said colorimetric indicator component into solution with said powdered ion exchange resin powder, and wherein said colorimetric indicator component is adsorbed into said ion exchange resin.