Anticalculus oral compositions
First Claim
1. An anticalculus oral composition which comprise an orally acceptable vehicle or base for such composition, an effective anticalculus proportion of at least about 0.01% to about 5% by weight of an orally acceptable azacycloalkane-2,2-diphosphonic compound (AAP) selected from the group consisting of compounds of the formula:
- ##STR3## wherein R is selected from the group consisting of hydrogen and alkyls of 1 to 3 carbon atoms and n is an integer from 3 to 5, and orally acceptable salts thereof and a synthetic anionic polymeric polycarboxylate (SAPP) of a molecular weight in the range of about 5,000-2,000,000, in a proportion of at least about 0.1% to about 5% by weight, which is effective to increase the anticalculus action of the AAP in said composition.
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Accused Products
Abstract
An anticalculus oral composition, which is preferably a toothpaste or a mouthrinse, includes an effective anticalculus azacycloalkane-2,2-diphosphonic acid or a salt thereof, preferably azacycloheptane-2,2-diphosphonic acid, and a polymeric polycarboxylate, which is preferably a linear copolymer of maleic anhydride and vinyl methyl ether of a molecular weight in the range of about 5,000-2,000,000, preferably about 30,000-1,500,000. The copolymer surprisingly increases the anticalculus effectiveness of the azacycloalkane-2,2-diphosphonic acid or salt thereof in such compositions, even at comparatively low concentrations of both such materials.
Also within the invention is a process for applying such compositions to the teeth, and it has been shown by both in vitro and in vivo testing that significant and repeatable improvements in anticalculus effects are obtained by such processes, compared to control processes in which either of the active components mentioned is employed alone in the described anticalculus oral compositions.
83 Citations
21 Claims
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1. An anticalculus oral composition which comprise an orally acceptable vehicle or base for such composition, an effective anticalculus proportion of at least about 0.01% to about 5% by weight of an orally acceptable azacycloalkane-2,2-diphosphonic compound (AAP) selected from the group consisting of compounds of the formula:
- ##STR3## wherein R is selected from the group consisting of hydrogen and alkyls of 1 to 3 carbon atoms and n is an integer from 3 to 5, and orally acceptable salts thereof and a synthetic anionic polymeric polycarboxylate (SAPP) of a molecular weight in the range of about 5,000-2,000,000, in a proportion of at least about 0.1% to about 5% by weight, which is effective to increase the anticalculus action of the AAP in said composition.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
Specification