Antigen-based treatment for adiposity

• US 5,096,706 A
• Filed: 03/25/1986
• Issued: 03/17/1992
• Est. Priority Date: 03/25/1986
• Status: Expired due to Term

• Current Assignee: British Technology Group Ltd. (Boston Scientific Corporation)
• Original Assignee: National Research Development Corporation
• Inventors: Flint, David J.
• Primary Examiner(s): Kepplinger, Esther L.
• Assistant Examiner(s): KUSHAN, JEFFREY
• Application Number:
  US06/843,790
• Time in Patent Office: 2,184 Days
• Field of Search: 530/403, 530/387, 424/85, 424/88, 424/86, 424/89, 424/90, 424/93, 514/21
• US Class Current: 424/193.1
• CPC Class Codes: A61K 39/0012 Lipids; Lipoproteins

Abstract

A method of preventing, controlling or reducing adiposity in which an animal or human subject is treated with an immunogen which is a modified or unmodified antigenic substance obtainable from adipose tissue of an individual of the same species as the subject or of a species which is closely related phylogenetically to the species of the subject or which is a modified or unmodified antiidiotypic antibody or fragment thereof to an antibody raised against said antigenic substance whereby an immune response is elicited in the subject effective to prevent, control or reduce adiposity.

Claims

1. A method of preventing, controlling or reducing adiposity in animals, comprising administering to said animal an effective amount of a fat cell-specific immunogen which is an antigenic substance selected from the group consisting of plasma membranes of white fat cells of an individual of the same species as said animal or of a species which is closely related phylogenetically to the species of said animal and a fat cell-specific determinant of said plasma membranes, said immunogen being effective to reduce the weight and/or number of fat cells of said animal and thus elicit an immune response in said animal effective to prevent, control or reduce adiposity, and wherein when said animal is meat-producing, subsequently slaughtering said animal for meat.

2. The method according to claim 1, in which said an antigenic substance is of an individual of the same species as the animal being treated and modified by conjugation to a carrier which is capable of conferring hapten characteristics upon small molecules.

3. The method according to claim 2, wherein the carrier is a serum albumin.

4. The method according to claim 1, wherein said animal is a lamb, calf or pig.

5. A method of preventing, controlling or reducing adiposity in animals, comprising administering to said animal an effective amount of a fat cell-specific immunogen which is an antigenic substance selected from the group consisting of plasma membranes of white fat cells of an individual of the same species as said animal or of a species which is closely related phylogenetically to the species of said animal and a fat cell-specific determinant of said plasma membranes, said immunogen being effective to reduce the weight and/or number of fat cells of said animal and thus prevent, control or reduce adiposity, said antigenic substance being conjugated to a carrier.

6. The method according to claim 5, wherein the carrier is a serum albumin.

7. The method according to claim 5, wherein said animal is a lamb, calf or pig.