Method and means for treating alcoholism by extinguishing the alcohol-drinking response using a transdermally administered opiate antagonist
First Claim
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1. A method for treating alcoholism by extinguishing the alcohol-drinking response, comprising the steps of:
- transdermally administering to a subject suffering from alcoholism, an opiate antagonist selected from the group consisting of naloxone, naltrexone, cyclazocine, diprenorphine, etazocine, levalorphan, metazocine, nalorphine, and salts thereof, in a daily dosage sufficient to block the stimulatory effect of alcohol, said opiate antagonist being administered by a transdermal delivery means containing a fixed dose of the antagonist, a vehicle and a permeation enhancer;
while the amount of antagonist in the subject'"'"'s body is sufficient to block the stimulatory effect of alcohol, having the subject drink an alcoholic beverage; and
continuing the steps of administration of the opiate antagonist and drinking of an alcoholic beverage until the alcohol-drinking response is extinguished.
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Abstract
A method for treating alcoholism by extinguishing the alcohol-drinking response in which an opiate antagonist is transdermally administered to a subject and a device for transdermally administering the antagonist. The device is a package containing a fixed dose of opiate antagonist, a vehicle and a permeation enhancer.
168 Citations
12 Claims
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1. A method for treating alcoholism by extinguishing the alcohol-drinking response, comprising the steps of:
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transdermally administering to a subject suffering from alcoholism, an opiate antagonist selected from the group consisting of naloxone, naltrexone, cyclazocine, diprenorphine, etazocine, levalorphan, metazocine, nalorphine, and salts thereof, in a daily dosage sufficient to block the stimulatory effect of alcohol, said opiate antagonist being administered by a transdermal delivery means containing a fixed dose of the antagonist, a vehicle and a permeation enhancer; while the amount of antagonist in the subject'"'"'s body is sufficient to block the stimulatory effect of alcohol, having the subject drink an alcoholic beverage; and continuing the steps of administration of the opiate antagonist and drinking of an alcoholic beverage until the alcohol-drinking response is extinguished. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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Specification