Rate-responsive pacemaker with circuitry for processing multiple sensor inputs

• US 5,097,831 A
• Filed: 04/16/1990
• Issued: 03/24/1992
• Est. Priority Date: 04/16/1990
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Siemens Pacesetter, Inc. (Abbott Laboratories Incorporated)
• Inventors: Lekholm, Anders
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): SCHAETZLE, KENNEDY
• Application Number:
  US07/510,337
• Time in Patent Office: 708 Days
• Field of Search: 128/419 PG
• US Class Current: 607/18
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters
• CPC Class Codes: A61N 1/3704 Circuits specially adapted therefor, e.g. for sensitivity control

Abstract

An implantable rate-responsive pacemaker is disclosed wherein two or more sensors indicative of physiological demand are utilized in a fashion designed to realize the advantages of both sensors in a circuit producing a rate command signal which is used to operate the pacemaker at an optimum pacing rate which will closely match physiological need of the patient. A switch matrix monitors processed signals from the sensors to select a unique set of numerical coefficients indicated by the processed sensor signals. The selected set of numerical coefficients are used as weighting factors to weight the impact of each of the sensor signals in the calculation of a selected rate.

Claims

1. A rate-responsive pacemaker for stimulating the heart of a patient, said pacemaker comprising:

pulse generating means for generating and delivering stimulation pulses to the patient'"'"'s heart in response to a selected rate signal;

a first sensor means for sensing a first physiological parameter of a patient and producing a first signal in response thereto;

a second sensor means for sensing a second physiological parameter of a patient and producing a second signal in response thereto;

first processing means for processing said first signal to provide a first switch matrix input signal indicative of one or more characteristics of said first signal;

second processing means for processing said second signal to provide a second switch matrix input signal indicative of one or more characteristics of said second signal;

an addressable switch matrix having as inputs said first and second switch matrix input signals and having as an output a unique set of numerical coefficients indicated by the values of said first and second switch matrix input signals; and

means for computing a selected rate signal based on said first and second signals and said unique set of numerical coefficients, said selected rate signal being supplied to said pulse generating means.

2. A rate-responsive pacemaker as defined in claim 1, wherein said addressable switch matrix comprises:

memory for storing a plurality of sets of numerical coefficients; and

rate memory logic means for selecting the one of said plurality of sets of numerical coefficients stored in said memory which corresponds to the values of said first and second switch matrix input signals.

3. A rate-responsive pacemaker as defined in claim 2, wherein the values of said plurality of sets of numerical coefficients stored in said memory are programmable.

4. A rate-responsive pacemaker as defined in claim 2, wherein each of said plurality of sets of numerical coefficients comprises two numerical coefficients.

5. A rate-responsive pacemaker as defined in claim 4, wherein said numerical coefficients are weighting factors for said first and second signals.

6. A rate-responsive pacemaker as defined in claim 4, wherein said selected rate signal is calculated according to the formula X·

S₁ +Y·

S₂ where X and Y are the unique set of numerical coefficients, S₁ is the first signal, and S₂ is the second signal.

7. A rate-responsive pacemaker as defined in claim 2, wherein each of said plurality of sets of numerical coefficients comprises three numerical coefficients.

8. A rate-responsive pacemaker as defined in claim 7, wherein two of said numerical coefficients are weighting factors for said first and second signals, and the third of said numerical coefficients is an offset factor.

9. A rate-responsive pacemaker as defined in claim 8, wherein said selected rate signal is calculated according to the formula X·

S₁ +Y·

S₂ +Z were X and Y are the two weighting factors in the unique set of numerical coefficients, S₁ is the first signal, S₂ is the second signal, and Z is the offset factor in the unique set of numerical efficients.

10. A rate-responsive pacemaker as defined in claim 1, wherein said first sensor means comprises:

an activity sensor.

11. A rate-responsive pacemaker as defined in claim 10, wherein said second sensor means comprises:

a temperature sensor.

12. A rate-responsive pacemaker as defined in claim 10, wherein said second sensor means comprises:

a respiratory minute volume sensor.

13. A rate-responsive pacemaker as defined in claim 10, wherein said second sensor means comprises:

a QT interval sensor.

14. A rate-responsive pacemaker as defined in claim 10, wherein said second sensor means comprises:

a respiratory rate sensor.

15. A rate-responsive pacemaker as defined in claim 10 wherein said second sensor means comprises:

a stroke volume sensor.

16. A rate-responsive pacemaker as defined in claim 10, wherein said second sensor means comprises:

a blood pressure sensor.

17. A rate-responsive pacemaker as defined in claim 1, wherein one of said first and second sensor means comprises:

a blood oxygen saturation sensor.

18. A rate-responsive pacemaker as defined in claim 1, wherein one of said first and second sensor means comprises:

a blood oxygen partial pressure sensor.

19. A rate-responsive pacemaker as defined in claim 1 wherein said first sensor means has a relatively fast response and said second sensor means has a relatively slow response.

20. A rate-responsive pacemaker as defined in claim 19, wherein said first sensor means comprises one of the sensors from the group consisting of an activity sensor, a blood oxygen saturation sensor, a blood oxygen partial pressure sensor, and a p CO₂ sensor.

21. A rate-responsive pacemaker as defined in claim 19, wherein said second sensor means comprises one of the sensors from the group consisting of a respiratory minute volume sensor, a temperature sensor, a pH sensor, and a respiration rate sensor.

22. A rate-responsive pacemaker as defined in claim 1, wherein said first sensor means has a highly accurate response for low levels of exercise and said second sensor means has a highly accurate-response for high levels of exercise.

23. A rate-responsive pacemaker as defined in claim 22, wherein said first sensor means comprises one of the sensors from the group consisting of an activity sensor, a blood oxygen saturation sensor, a blood oxygen partial pressure sensor, and a pCO₂ sensor.

24. A rate-responsive pacemaker as defined in claim 22, wherein said second sensor means comprises one of the sensors from the group consisting of a respiratory minute volume sensor, a pH sensor, and a temperature sensor.

25. A rate-responsive pacemaker as defined in claim 1, wherein said first conversion means comprises:

a first amplifier for amplifying said first signal, said first amplifier having a first amplifier output;

a first filter for filtering said first amplifier output, said first filter having a first filter output; and

first linearizing means for linearizing said first filter output.

26. A rate-responsive pacemaker as defined in claim 1, wherein said second conversion means comprises:

a second amplifier for amplifying said second signal, said second amplifier having a second amplifier output;

a second filter for filtering said second amplifier output, said second filter having a second filter output; and

second linearizing means for linearizing said second filter output.

27. A rate-responsive pacemaker as defined in claim 1, additionally comprising:

a reaction and recovery time circuit installed between said addressable rate matrix and said pulse generating means, said reaction and recovery time circuit for limiting the rate at which said selected rate signal supplied to said pulse generating means will be allowed to rise and fall.

28. A rate-responsive pacemaker for stimulating the heart of a patient, said pacemaker comprising:

pulse generating means for generating and delivering stimulation pulses to the patient'"'"'s heart in response to a selected rate signal;

a first sensor means for sensing a first physiological parameter of a patient and producing a first signal in response thereto;

a second sensor means for sensing a second physiological parameter of a patient and producing a second signal in response thereto;

first processing means for processing said first signal to provide a first switch matrix input signal indicative of one or more characteristics of said first signal;

second processing means for processing said second signal to provide a second switch matrix input signal indicative of one or more characteristics of said second signal;

an addressable switch matrix having as inputs said first and second switch matrix input signals, said addressable switch matrix containing a plurality of sets of numerical coefficients therein, said addressable switch matrix having as an output a particular set of two numerical coefficients which is indicated in said addressable switch matrix by the values of said first and second switch matrix input signals; and

means for computing a selected rate signal by first computing the product of one of said two numerical coefficients and said first signal, secondly computing the product of the other of said two numerical coefficients and said second signal, and thirdly adding the products together, said selected rate signal being supplied to said pulse generating means.

29. A rate-responsive pacemaker for stimulating the heart of a patient, said pacemaker comprising:

pulse generating means for generating and delivering stimulation pulses to the patient'"'"'s heart in response to a selected rate signal;

a first sensor means for sensing a first physiological parameter of a patient and producing a first signal in response thereto;

a second sensor means for sensing a second physiological parameter of a patient and producing a second signal in response thereto;

a third sensor means for sensing a third physiological parameter of a patient and producing a third signal in response thereto;

first processing means for processing said first signal to provide a first switch matrix input signal indicative of one or more characteristics of said first signal;

second processing means for processing said second signal to provide a second switch matrix input signal indicative of one or more characteristics of said second signal;

third processing means for processing said third signal to provide a third switch matrix input signal indicative of one or more characteristics of said third signal;

an addressable switch matrix having as inputs said first, second, and third switch matrix input signals and having as an output a unique set of numerical coefficients indicated by the values of said first, second, and third switch matrix input signals; and

means for computing a selected rate signal based on said first, second, and third signals and said numerical coefficients, said selected rate signal being supplied to said pulse generating means.

30. A rate-responsive pacemaker for stimulating the heart of a patient, said pacemaker comprising:

pulse generating means for generating and delivering stimulation pulses to the patient'"'"'s heart in response to a selected rate signal;

a first sensor means for sensing a first physiological parameter of a patient and producing a first signal in response thereto;

a second sensor means for sensing a second physiological parameter of a patient and producing a second signal in response thereto;

first processing means for processing said first signal to provide a first switch matrix input signal indicative of one or more characteristics of said first signal;

an addressable switch matrix having as an input said first switch matrix input signal and having as an output a unique set of numerical coefficients indicated by the value of said first switch matrix input signal; and

means for computing a selected rate signal based on said first and second signals and said numerical coefficients, said selected rate signal being supplied to said pulse generating means.

31. A method of selecting the stimulating rate of a rate-responsive pacemaker for stimulating the heart of a patient, comprising:

generating and delivering stimulation pulses to the patient'"'"'s heart in response to a selected rate signal;

sensing a first physiological parameter of a patient and producing a first signal in response thereto;

sensing a second physiological parameter of a patient and producing a second signal in response thereto;

processing said first signal to provide a first switch matrix input signal indicative of one or more characteristics of said first signal;

processing said second signal to provide a second switch matrix input signal indicative of one or more characteristics of said second signal;

providing said first and second switch matrix input signals as inputs to an addressable switch matrix, said addressable switch matrix having as an output a unique set of numerical coefficients indicated by the values of said first and second switch matrix input signals; and

computing a selected rate signal based on said first and second signals and said numerical coefficients, said selected rate signal being supplied to said pulse generating means.