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D-luciferin derivatives, their application and processes for the detection of ligands marked with an enzyme in the determination of biochemical substances

  • US 5,098,828 A
  • Filed: 08/19/1987
  • Issued: 03/24/1992
  • Est. Priority Date: 10/24/1985
  • Status: Expired due to Fees
First Claim
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1. D-luciferin derivatives which are enzyme substrates, which release luciferin upon reaction with enzyme and which have a formula (I):

  • ##STR35## and wherein said luciferin derivative is D-luciferyl-L-N-alpha-arginine (R1 is L-H-alpha-arginin, R2 is H);

    D-luciferyl-L-phenylalanin (R1 is --NH--CH(CH2 C6 H5)--COOH, R2 is H);

    D-luciferyl-L-methionine (R1 is --NH--CH((CH2 SCH3)--COOH, R2 is H);

    D-luciferyl-L-glycine (R1 is --NH--CH2 COOH, R2 is H);

    D-luciferin-O-sulfate (R1 is OH, R2 is --SO2 --OH);

    D-luciferin-O-phosphate (R1 is --OH, R2 is --P(O)--(OH)2);

    D-luciferin-O-(C1)glucose(R1 is OH and R2 is glucose);

    orD-luciferin-O-(C1)galactose (R1 is OH and R2 is galactose).

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