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Process for the production of thyroglobulin

  • US 5,099,001 A
  • Filed: 12/28/1989
  • Issued: 03/24/1992
  • Est. Priority Date: 12/28/1989
  • Status: Expired due to Fees
First Claim
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1. In a process for the production of thyroglobulin having a thyroxine-to-triiodothyronine ratio (T4 /T3 ratio) comprising saline digestion mammalian thyroid glands to release thyroglobulin, precipitation of thyroglobulin by pH adjustment, denaturation of thyroglobulin by heating, and defatting thyroglobulin by extraction with alcohol, the improvement comprising:

  • correlating the precipitating, denaturing, and defatting steps whereby the duration of the precipitating step is selected to produce thyroglobulin having a first T4 /T3 ratio substantially greater than 2.6 and the durations of the denaturing and defatting steps are selected in correlation with said precipitating step duration to lower said T4 /T3 value greater than 2.6 to a final value in the range of 2.6-3.4 and absolute levels of not less than about 0.7 μ

    g/mg liothyronine and not less than about 2.1 μ

    g/mg levothyroxine.

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