Synthesis of amino acid-derived bioerodible polymers

• US 5,099,060 A
• Filed: 06/12/1990
• Issued: 03/24/1992
• Est. Priority Date: 06/12/1990
• Status: Expired due to Term

• Current Assignee: Rutgers State University of New Jersey
• Original Assignee: Rutgers University
• Inventors: Kohn, Joachim B., Pulapura, Satish K. K.
• Primary Examiner(s): NOT, DEFINED
• Application Number:
  US07/536,425
• Time in Patent Office: 651 Days
• Field of Search: 560/40
• US Class Current: 560/40
• CPC Class Codes: A61K 9/204 Polyesters, e.g. poly(lactide-co-glycolide)
• CPC Class Codes: C07C 235/34 having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
• CPC Class Codes: C07C 237/20 the carbon skeleton containing six-membered aromatic rings
• CPC Class Codes: C07C 237/22 having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated peptides C07K
• CPC Class Codes: C07C 271/22 to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
• CPC Class Codes: C08G 63/6854 derived from polycarboxylic acids and polyhydroxy compounds
• CPC Class Codes: C08G 64/12 containing nitrogen
• CPC Class Codes: C08G 69/44 Polyester-amides

Abstract

Novel amino acid-derived polycarbonates and amino acid-derived diphenol compound starting materials from which the polycarbonates are polymerized. Polymer blends of the amino acid-derived polycarbonates with polyiminocarbonates prepared from identical amino acid-derived diphenol starting materials.

Claims

1. A diphenol compound comprising an amino acid derivative of the formula:

##STR7## wherein R₁ is an alkyl group up to 18 carbon atoms in length.

2. The diphenol compound of claim 1, wherein R₁ is --(CH₂)₅ --CH₃.