Method for determining the arterial blood pressure in a non-invasive manner
First Claim
1. A method for determining at each instant the blood pressure p(t) in an artery at a given point in its course including the following succession of steps:
- a) measuring non-invasively and simultaneously during a cardiac cycle a first diameter D1 (t) of the artery at a first location and a second diameter D2 (t) of the artery at a second location, said first and second locations being separated by a distance Δ
x, to produce signals representing said diameters, said measuring of said first and second diameters comprising directing ultrasonic waves toward said artery at said first and second locations and sensing echoes of said waves reflected from a wall of said artery to produce electrical signals representing said diameters,b) storing in a memory device at successive instants of the cardiac cycle pairs of values of said signals each pair including a value D1 (t) of said first diameter and a value D2 (t) of said second diameter,c) for the diameter pairs thus stored, seeking the value of the diameter D2 (t+Δ
t) such that D2 (t+Δ
t)=D1 (t) in order thus to determine the time delay Δ
t(D) between the diameter measurements of each of these pairs,d) calculating on the basis of said time delays Δ
t(D) and of each value of the first diameter D1 (t) initially stored during step b) the propagation velocity c(D) of the pressure wave generated by the cardiac function in taking into account said distance Δ
x by means of the relation c(D)=Δ
x/Δ
t(D),e) choosing a mathematical relationship D(p)=D(p, α
, β
, γ
, . . . ) which takes the behavior of the artery into account,f) determining an algebraic expression c(D)=c(D, α
, β
, γ
, . . . ) expressing the theoretical propagation velocity of the pressure wave as a function of the diameter from the preceding mathematical relationship chosen in step e),g) calculating by a mathematical adjustment method on the propagation velocity values obtained during step d) the parameters α
, β
, γ
, . . . from the algebraic expression previously obtained in step f), andh) calculating the blood pressure p(t) for each value of first diameters D1 (t) previously stored in step b) in replacing the parameters of the mathematical relationship d(p)=D(pm α
, β
, γ
. . . ) chosen in step e) by their values.
1 Assignment
0 Petitions
Accused Products
Abstract
This method for establishing blood pressure in an artery employs the measurement results from two non-invasive sensors (5, 6) of artery diameter at two closely spaced locations (3, 4) separated by a distance Δx. The method provides for measuring the time spread Δt(7) between each pair of diameter measurements and establishing the propagation velocity of the pressure wave (9). Next, this value is compared with an expression (11) of the form c(D)= c(D, α, β, γ, . . . ) which takes into account the physical behavior of the artery. This comparison permits one, following adjustment (12) based on a mathematical procedure for minimizing spreads, to calculate the parameters α, β, γ, . . . of the relation given hereinabove. By replacing the parameters α, β, γ, . . . by their values in a relation (10) D(p)= D(p, α, β, γ, . . . ) and in employing the measurement results from a diameter sensor, one may deduce the blood pressure value p(t) at each instant of the cardiac cycle. The blood pressure value together with the corresponding value of the artery diameter permit tracing a pressure-diameter curve (14) by means of which the mechanical properties of the artery may be measured.
33 Citations
6 Claims
-
1. A method for determining at each instant the blood pressure p(t) in an artery at a given point in its course including the following succession of steps:
-
a) measuring non-invasively and simultaneously during a cardiac cycle a first diameter D1 (t) of the artery at a first location and a second diameter D2 (t) of the artery at a second location, said first and second locations being separated by a distance Δ
x, to produce signals representing said diameters, said measuring of said first and second diameters comprising directing ultrasonic waves toward said artery at said first and second locations and sensing echoes of said waves reflected from a wall of said artery to produce electrical signals representing said diameters,b) storing in a memory device at successive instants of the cardiac cycle pairs of values of said signals each pair including a value D1 (t) of said first diameter and a value D2 (t) of said second diameter, c) for the diameter pairs thus stored, seeking the value of the diameter D2 (t+Δ
t) such that D2 (t+Δ
t)=D1 (t) in order thus to determine the time delay Δ
t(D) between the diameter measurements of each of these pairs,d) calculating on the basis of said time delays Δ
t(D) and of each value of the first diameter D1 (t) initially stored during step b) the propagation velocity c(D) of the pressure wave generated by the cardiac function in taking into account said distance Δ
x by means of the relation c(D)=Δ
x/Δ
t(D),e) choosing a mathematical relationship D(p)=D(p, α
, β
, γ
, . . . ) which takes the behavior of the artery into account,f) determining an algebraic expression c(D)=c(D, α
, β
, γ
, . . . ) expressing the theoretical propagation velocity of the pressure wave as a function of the diameter from the preceding mathematical relationship chosen in step e),g) calculating by a mathematical adjustment method on the propagation velocity values obtained during step d) the parameters α
, β
, γ
, . . . from the algebraic expression previously obtained in step f), andh) calculating the blood pressure p(t) for each value of first diameters D1 (t) previously stored in step b) in replacing the parameters of the mathematical relationship d(p)=D(pm α
, β
, γ
. . . ) chosen in step e) by their values. - View Dependent Claims (2, 3, 4)
-
-
5. A method for non-invasively determining at each instant in a cardiac cycle blood pressure values representing the blood pressure in an artery at a given point in its course, said method comprising:
-
disposing first and second sensors outside said artery at first and second points separated by a distance X along the course of said artery, said sensors producing output signals representing the diameters of said artery at said first and second points, respectively; repeatedly and simultaneously sampling said output signals from said sensors over an interval including at least one cardiac cycle to produce pairs of values representing the sensed diameters at said first and second points; storing said pairs of values in a computer memory; determining, from said stored pairs of values, the delay between a time said first sensor produces an output signal of a given magnitude and a time said second sensor produces an output signal of the same magnitude, and producing a delay signal representing said delay; determining from said delay signal and said value representing said distance X, the actual propagation velocity between said first and second points of a pressure wave generated by the cardiac function; choosing a mathematical relationship D(p)=D(p, 60 , β
, γ
. . . ) where α
, β
, γ
. . . are parameters expressing behavior of the artery and p represents pressure;determining from said mathematical relationship the theoretical velocity of propagation of said pressure wave as a function of the diameter of the artery; determining from said theoretical velocity of propagation and said actual propagation velocity, numerical values of said parameters; and
,calculating said blood pressure values by substituting said numerical values of said parameters in said mathematical relationship. - View Dependent Claims (6)
-
Specification