Implantable device for administration of drugs or other liquid solutions

• US 5,100,392 A
• Filed: 12/08/1989
• Issued: 03/31/1992
• Est. Priority Date: 12/08/1989
• Status: Expired due to Fees

• Current Assignee: Biosynthesis Incorporated
• Original Assignee: Biosynthesis Incorporated
• Inventors: Orth, Jeffrey L., Hoffer, Richard E., Triolo, Philip M.
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): NOT, DEFINED
• Application Number:
  US07/447,635
• Time in Patent Office: 844 Days
• Field of Search: 604/157, 604/93, 604/175, 604/264, 604/891.1, 128/769, 128/899
• US Class Current: 604/175
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61M 39/0208 Subcutaneous access sites for injecting or removing fluids transcutaneous access sites A61M39/0247; implantable infusion devices A61M5/14276

Abstract

An implantable device for administering drugs or other substances to body tissues of a patient is disclosed. The device is designed to allow controlled ingrowth of connective tissue into the device, and a solution may be pumped or injected into the device where the solution is diffused through the ingrown connective tissue and out into the body.

Claims

1. An implantable device for administering substances to body tissues of a patient comprising:

an outer casing defining an inner space, said casing being formed of porous synthetic material having pores formed and sized for growth of body tissue through the pores of said synthetic material into said inner space, said outer casing having at least one opening therein which communicates with said inner space; and

an inlet catheter of non-porous synthetic material in communication with said opening of said outer casing to form a passageway for conveyance of substance between said inlet catheter and said inner space.

2. The device of claim 1 further comprising an outlet catheter of non-porous synthetic material in communication with an opening of said outer casing to form a second passageway for conveyance of substances between said inner space and said outlet catheter.

3. The device of claim 2 further comprising a pump connected to said inlet catheter for controlled administration of said substances to said inlet catheter.

4. The device of claim 2 further comprising at least one port means connected to said inlet catheter for injecting substances therein.

5. The device of claim 1 wherein said pores of said porous synthetic material range in size from about 60 microns to about 400 microns.

6. An implantable device for administering substances to body tissues of a patient comprising:

an outer casing of porous synthetic material having pores of sufficient size to allow growth of body tissue therethrough;

at least one tubule of synthetic material capable of allowing molecules of sufficiently small size to pass through said material while prohibiting growth of body tissue therethrough, said tubule having at least one open end, and said tubule being positioned within said outer casing;

a first collecting member in communication with said open end of said tubule, said collecting member having at least one aperture therein; and

an inlet catheter connected to said aperture of said collecting member to form a pathway for substances therebetween.

7. The device of claim 6, further comprising a plurality of tubules, said tubules being substantially parallel to each other within said outer casing.

8. The device of claim 7 wherein each said tubule has a second open end.

9. The device of claim 8 further comprising a second collecting member in communication with each of said second open ends of said tubules to form an intercommunication between said second open ends.

10. The device of claim 9 wherein said second collecting member has an aperture formed therein, said aperture being connected to an outlet catheter for conveyance of substances between said second open ends of said tubules and said outlet catheter.

11. The device of claim 9 wherein said first collecting member has a second aperture to which is connected an outlet catheter for conveyance of substances between said tubules and said outlet catheter.

12. The device of claim 6 wherein said outer casing defines a hollow inner space.

13. The device of claim 6 wherein said synthetic material of said tubule is capable of allowing passage of molecules ranging from a molecular weight of about 10 to a molecular weight of about 100,000.

14. The device of claim 6 wherein said synthetic material of said tubule is capable of prohibiting blood cell components from passing therethrough.

15. An implantable device for administering substances to body tissues of a patient comprising:

a hollow outer casing of porous synthetic material having pores of sufficient size to allow growth of body tissue therethrough;

a hollow inner casing of synthetic material capable of allowing molecules of sufficiently small size to pass through said material while prohibiting growth of body tissue therethrough, said inner casing being positioned within said outer casing; and

an inlet catheter of non-porous material in communication with said hollow inner casing to form a pathway for conveyance of substances therebetween.

16. The device of claim 15 further comprising an outlet catheter of non-porous material in communication with said hollow inner casing to form a pathway for conveyance of substances therebetween.

17. The device of claim 16 further comprising a pump connected to said inlet catheter for controlled administration of substances to said inlet catheter.

18. The device of claim 17 further comprising at least one port means connected to said inlet catheter for injecting substances therein.

19. The device of claim 15 wherein synthetic material of said hollow outer casing range in size from about 60 microns to about 500 microns.

20. The device of claim 15 wherein said synthetic material of said hollow inner casing is capable of allowing passage of molecules ranging from a molecular weight of about 10 to a molecular weight of about 100,000.

21. The device of claim 15 wherein said synthetic material of said hollow inner casing is capable of prohibiting blood cell components from passing therethrough.

22. A method of implanting an implantable device for administering substances to body tissues of a patient comprising:

obtaining a device comprising an outer casing of porous synthetic material capable of allowing body tissue to grow into the pores of the synthetic material, an inlet catheter and outlet catheter;

making a surgical incision in the area of the patient where implantation is desired;

forming a cavity in the tissue area for placement of the device;

placing the device within the cavity;

draping excess tissue from the surrounding area about the device to encourage tissue ingrowth;

securing said excess tissue in place about the device;

placing said inlet catheter and said outlet catheter in close proximity to the skin of the patient for ease of access postoperatively;

suturing said inlet catheter and said outlet catheter in place; and

suturing the incision area closed.