System for monitoring and controlling blood glucose

• US 5,101,814 A
• Filed: 08/11/1989
• Issued: 04/07/1992
• Est. Priority Date: 08/11/1989
• Status: Expired due to Term

• Current Assignee: Cb-Carmel Biotechnology Limited
• Original Assignee: Yoram Palti
• Inventors: Palti, Yoram
• Primary Examiner(s): Cohen, Lee S.
• Application Number:
  US07/392,828
• Time in Patent Office: 970 Days
• Field of Search: 128/635, 604/31, 604/50, 604/66, 604/67, 204/403, 204/415
• US Class Current: 600/347
• CPC Class Codes: A61B 5/0017 transmitting optical signals transmission by light H04B10/00
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/4839 combined with drug delivery

Abstract

Systems are disclosed which utilize implanted glucose sensitive living cells to monitor blood glucose levels. The implanted cells produce a detectable electrical or optical signal in response to changes in glucose concentration in surrounding tissue. The signal is then detected and interpreted to give a reading indicative of blood glucose levels. Capsules containing glucose sensitive cells and electrodes for detecting electrical activity are also disclosed. Methods of monitoring blood glucose are also described utilizing the systems and capsules disclosed.

Claims

1. A system for monitoring glucose levels in a patient'"'"'s body tissues, said system comprising:

implantable glucose sensitive living animal cells capable of producing an electrical or optical signal in response to the glucose concentration in the medium surrounding said cells in the patient; and

means for detecting said electrical or optical signal.

2. The system of claim 1 wherein said signal is an electrical signal.

3. The system of claim 2 wherein said cells are contained in a capsule and wherein the means for detecting said electrical or optical signal comprises collecting means in said capsule for collecting said electrical signal from said cells.

4. The system of claim 3 wherein said collecting means are metal electrodes in contact with said cells such that said signal can be measured as a potential difference between said electrodes.

5. The system of claim 4 wherein the means for detecting said electrical signal further comprises an implantable signal pickup device connected to said electrodes for processing said signal for transmission.

6. The system of claim 5 wherein the means for detecting said electrical signal further comprises transmission means connected to said pickup device for transmitting said processed signal through a body surface.

7. The system of claim 1 wherein said signal is optical.

8. The system of claim 7 wherein said signal results from changes in the optical qualities of said cells.

9. The system of claim 8 wherein said optical qualities are changed by dyes in or on the membranes of said cells that are affected by changes in the membrane potential of said membranes.

10. The system of claim 8 wherein the means for detecting said optical signal comprises an implantable optical sensing device positioned with respect to said cells so as to detect and process said signal for transmission.

11. The system of claim 10 wherein the means for detecting said optical signal further comprises transmission means connected to said implantable optical sensing device for transmitting said processed signal through a body surface.

12. The system of claims 6, 7 or 11 wherein the means for detecting said electrical or optical signal comprises sensor means for detecting said transmitted signal through said body surface and for correlating said transmitted signal to said glucose concentration.

13. The system of claim 12 wherein said sensor means comprises:

detector means for detecting said transmitted signal;

processor means connected to said detector means for correlating said transmitted signal to said glucose concentration; and

output means connected to said processor means for reporting said glucose concentration.

14. The system of claim 5 further comprising an insulin pump connected to said pickup device such that said pump delivers a dosage of insulin appropriate to said glucose concentration.

15. The system of claim 10 further comprising an insulin pump connected to the implantable optical sensing device of the means for detecting said electrical or optical signal, such that said pump delivers a dosage of insulin appropriate to said glucose concentration.

16. The system of claim 1 wherein said cells are selected from the group comprising beta cells, alpha cells and taste cells.

17. The system of claim 16 wherein said cells are beta cells.

18. A method of monitoring the glucose level of a patient, said method comprising:

implanting into said patient glucose sensitive living animal cells capable of producing an electrical or optical signal in response to glucose concentration in the medium surrounding said cells in the patient;

detecting said signal; and

correlating said signal with said glucose concentration.

19. The method of claim 18 wherein said signal is detected through a body surface by an external signal sensor.

20. The method of claim 19 wherein said signal is processed by said sensor and correlated with said corresponding glucose concentration.

21. The method of claim 18 wherein the electrical or optical signal is detected by an implantable signal pickup device that processes said signal for transmission through a body surface.

22. The method of claim 21 wherein said processed signal is transmitted through said body surface and is sensed externally thereof external signal sensor.

23. The method of claim 22 wherein said transmitted signal is a sensor correlated with said corresponding glucose concentration.

24. A method of administering a dosage of insulin, said method comprising:

implanting into said patient glucose sensitive living animal cells capable of producing a signal in response to glucose concentration in the medium surrounding said cells;

detecting said signal;

correlating said signal with said glucose concentration; and

administering said dosage of insulin at a level appropriate to said glucose concentration.

25. The method of claim 24 wherein said dosage is administered by an implanted insulin pump.