Methods and apparatus for nonivasive monitoring of dynamic cardiac performance

• US 5,101,828 A
• Filed: 04/11/1991
• Issued: 04/07/1992
• Est. Priority Date: 04/11/1991
• Status: Expired due to Fees

• Current Assignee: Rutgers The State University of New Jersey A Non-Profit Corporation of NJ
• Original Assignee: Rutgers University
• Inventors: Qi, Yun, Cui, Qing, Welkowitz, Walter
• Primary Examiner(s): Jaworski, Francis
• Assistant Examiner(s): MANUEL, GEORGE C
• Application Number:
  US07/685,591
• Time in Patent Office: 362 Days
• Field of Search: 128/687, 128/668, 128/691, 128/702, 128/661.08, 364/413.02-413.06
• US Class Current: 600/481
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: G09B 23/28 for medicine

Abstract

Apparatus for noninvasively monitoring cardiovascular system parameters of a living subject comprises means for sensing waveforms externally of the body of the subject above the carotid and femoral arteries, means for non-invasively calibrating and digitizing the pulse waveforms, and a digital signal processor having means for converting the digitized, calibrated pulse information by Fast Fourier Transform to first and second sets of harmonically related blood pressure components in the frequency domain, means for comparing corresponding ones of the components in the first and second harmonically related sets to determine amplitude and phase transfer function components of the portion of the cardiovascular system between the carotid and femoral arteries, means for simulating the portion of the system by a hybrid electrical circuit model having at least three variable parameters, means for determining corresponding amplitude and phase transfer function components of the hybrid model and for adjusting the variable parameters so as to substantially match the transfer functions of the model and the portion of the cardiovascular system, and means for determining cardiac output utilizing the adjusted parameters of the hybrid model and the calibrated pulse information.

Claims

1. Apparatus for noninvasively monitoring cardiovascular system parameters of a living subject comprising:

means for sensing a first time varying pulse waveform in the vicinity of the carotid artery externally of the body of the subject and for converting the first pulse waveform to a first time varying electrical representation;

means for sensing a second time varying pulse waveform in the vicinity of the femoral artery externally of the body of the subject and for converting the second pulse waveform to a second time varying electrical representation;

means for digitizing said first and second time varying representations;

means for providing diastolic and systolic blood pressure measurements sensed externally of the body of the subject;

a digital signal processor having means for receiving said digitized first and second time varying representations and said measured blood pressure parameters and for calibrating said first and second digitized representations to provide first and second sets of time varying blood pressure representations, said processor further comprising means for converting said first and second sets of time varying blood pressure representations by Fast Fourier Transform to first and second sets of harmonically related blood pressure components in the frequency domain, means for comparing corresponding ones of said components in said first and second harmonically related sets to determine amplitude and phase transfer function components of the portion of the cardiovascular system between said carotid and femoral arteries, means for simulating said portion of said cardiovascular system by a hybrid electrical circuit model having at least three variable parameters, means for determining corresponding amplitude and phase transfer function components of said hybrid model of said portion of said system and for adjusting said parameters of said hybrid model so as to substantially match said transfer functions of said model and said portion of said cardiovascular system, and means for determining cardiac output utilizing said adjusted parameters of said hybrid model and said first set of time varying blood pressure representations.

2. Apparatus according to claim 1 wherein:

said mean for determining cardiac output comprises means utilizing said adjusted parameters for determining the equivalent input impedance of said hybrid model;

means for determining blood flow into said model during each pulse interval by dividing carotid blood pressure information by said input impedance and integrating the resultant flow information to determine stroke volume during each pulse.

3. Apparatus according to claim 2 wherein:

said means for determining cardiac output further comprises means for determining heart rate and means for determining the product of heart rate and stroke volume.

4. Apparatus according to claim 3 wherein:

said means for determining blood flow during each pulse interval further comprises means for converting harmonically related blood flow components in the frequency domain to time domain components by Inverse Fast Fourier Transform.

5. Apparatus according to claim 1 wherein said blood pressure calibrating means comprises means for determining peak and minimum pressure to voltage conversion parameters corresponding to said pulse waveform sensed in the vicinity of said carotid artery and wherein said peak pressure to voltage conversion parameter for said carotid pulse waveform is multiplied by a constant greater than unity to provide a corresponding conversion parameter for said pulse waveform sensed in the vicinity of said femoral artery.

6. Apparatus according to claim 5 wherein said constant is substantially equal to 1.06.

7. Apparatus according to claim 1 wherein said means for providing blood pressure parameters measured externally comprises an arm pressure cuff.

8. Apparatus according to claim 1 wherein said hybrid model is described by the pressure transfer equation ##EQU4## and said at least three variable parameters comprise R_a, C_a and K.

9. Apparatus according to claim 8 wherein said means for determining corresponding amplitude and phase transfer function components of said hybrid model comprises means for adjusting said three variable parameters according to an error optimization routine so as to substantially match said transfer functions.

10. A method for noninvasively monitoring cardiovascular system parameters of a living subject comprising the steps of:

externally sensing a carotid pulse and a femoral pulse of said subject;

converting said carotid and femoral pulses to respective carotid and femoral pulse electrical voltage waveforms;

digitizing both electrical voltage waveforms;

calibrating said digitized pulse waveforms with respect to amplitude;

subjecting said digitized waveforms to a Fast Fourier Transform by converting to harmonically related frequency components;

comparing amplitude and phase for each pair of carotid and femoral frequency components to derive measured phase and amplitude transfer functions for the subject;

storing in a computer a hybrid mathematical model of a human aorta;

automatically varying, by means of a matching optimization program stored in said computer, at least three predetermined parameters of the model;

deriving corresponding transfer function components of the model and comparing such components to the measured transfer function of the subject after each adjustment until a substantial match of the measured and calculated transfer functions is obtained;

determining the input impedance of the optimized model utilizing the adjusted, matched parameters;

determining aortic flow components from the impedance parameter of the model and the calibrated, measured carotid pressure information of the subject;

converting the aortic flow components to the time domain by Inverse Fast Fourier Transform; and

determining the time integral of the transformed flow information to provide stroke volume.

11. A method according to claim 10 wherein

said step of calibrating said digitized pulse waveforms comprises externally measuring diastolic and systolic blood pressure parameters externally of the body of a subject, determining a pressure to voltage coefficient for said carotid pulse information from said externally measured parameters, multiplying said coefficient by a factor of 1.06 and applying said multiplied coefficient to calibrate said digitized pulse waveform corresponding to said femoral pulse.

12. A method according to claim 10 wherein:

said hybrid mathematical model comprises a hybrid electrical circuit model in which the pressure transfer function is described by the equations;

##EQU5##

13. A method according to claim 12 wherein:

said step of automatically varying parameters comprises iteratively selecting different values for the parameters R_a, C_a and K so as to substantially match the transfer function of the subject.

14. A method according to claim 10 wherein:

said step of determining the input impedance of the optimized model comprises substituting adjusted optimized values of Ra, Ca and K into the equation;

##EQU6##

15. A method according to claim 14 wherein:

said step of determining aortic flow comprises dividing each transformed carotid pressure frequency component by the calculated input impedance of the optimized model to determine aortic flow frequency components, transforming said flow frequency components to the time domain and integrating said transformed flow in the time domain throughout at least one pulse interval to determine stroke volume.

16. A method according to claim 15 wherein:

said step of determining aortic flow further comprises measuring the time interval of at least one pulse waveform.