Solid state ion sensor with silicon membrane

• US 5,102,526 A
• Filed: 05/02/1990
• Issued: 04/07/1992
• Est. Priority Date: 05/02/1990
• Status: Expired due to Term

• Current Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Original Assignee: University of Michigan
• Inventors: Brown, Richard B., Cha, Geun-Sig
• Primary Examiner(s): Niebling, John
• Assistant Examiner(s): Bell, Bruce F.
• Application Number:
  US07/517,636
• Time in Patent Office: 706 Days
• Field of Search: 204/418, 204/403, 357/25, 435/288, 435/291, 435/180, 435/182
• US Class Current: 204/415
• CPC Class Codes: G01N 27/333 Ion-selective electrodes or membranes glass electrodes G01N27/36

Abstract

A silicone matrix is employed to form a substance-sensitive membrane which is particularly suited for installation on a solid state sensor. The ionophore may be a potassium ionophore, an ammonium ionophore or any other ionophore. The membrane may be coupled to the molecule of interest through a bioactive agent, such as an enzyme, an immunochemical, bacteria, antibody, virus, or antigen. The resulting substance-sensitive membrane has electrochemical properties which compare favorably to those of conventional PVC membranes, and exhibit significantly greater adhesion to glasses and semiconductor substrate materials. The improved adhesion will prolong the life of the sensors and prevent the formation of electrolyte shunts which have been known to render solid state sensors inoperative.

Claims

1. In an integrated circuit chemical sensor arrangement having an input electrode formed of a conductive material in the vicinity of a region formed of a silicon-based semiconductor material, a permselective membrane having a predetermined electrochemical property responsive to an ion through addition of an ionophore which is soluble in an organic solvent, and formed of a silicone-based compound arranged to be in adherence with said silicon-based semiconductor material and in electrical communication with said input electrode, for producing at said input electrode a voltage responsive to said electrochemical property.

2. The integrated circuit chemical sensor arrangement of claim 1 wherein said permselective membrane is further comprised of silanol-terminated polydimethylsiloxane.

3. The integrated circuit mechanical sensor arrangement of claim 1 wherein said permselective membrane is further comprised of a resistance-reducing additive.

4. The integrated circuit chemical sensor arrangement of claim 3 wherein said resistance-reducing additive is CN-derivatized silicone rubber.

5. The integrated circuit chemical sensor arrangement of claim 1 wherein said ionophore is a potassium ionophore.

6. The integrated circuit chemical sensor arrangement of claim 1 wherein said ionophore is an ammonium ionophore.

7. In a process for forming a substance-sensitive membrane for a solid state sensor arrangement, the process comprising the steps of:

first mixing an ionophore into polydimethylsiloxane; and

second mixing CN-derivatized silicone rubber into said polydimethylsiloxane.

8. The process of claim 7 wherein there is provided the further step of forming a membrane by depositing said mixture of said polydimethylsiloxane, said ionophore, and said CN-derivatized silicone rubber mixed therein onto a substrate.

9. The process of claim 7 wherein there is provided the further step of casting said mixture of said polydimethylsiloxane, ionophore, and CN-derivatized silicone rubber.

10. The process of claim 7 wherein said ionophore in said step of first mixing is an ammonium ionophore.

11. The process of claim 7 wherein said ionophore in said step of first mixing is a potassium ionophore.

12. The process of claim 7 wherein said ionophore is present in a proportion of 1 wt. % of the mixture.

13. A process for forming a substance-sensitive membrane for a solid state sensor arrangement, the process comprising the steps of:

first mixing into polydimethylsiloxane an ionophore in an amount of approximately 1 wt. %; and

second mixing CN-derivatized silicone rubber into said dissolved polydimethylsiloxane in an amount of approximately 10 wt. %.