Catechol derivatives, and preventive and remedial preparations for regressive disorders in the central nervous system containing the same
First Claim
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1. A pharmaceutical composition comprising:
- a catechol represented by the formula (D) ##STR9## wherein R7 is a lower alkyl group, a catechol having the formula (E) ##STR10## wherein R8 is a lower alkyl group excluding a methyl group, or a catechol having the formula (F) ##STR11## wherein R9 is a C3-4 alkyl group, and a pharmaceutically acceptable carrier.
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Abstract
Catechol derivatives which relate to the production of nerve growth factor in particular tissues of brain are disclosed.
Methods for the synthesis, data on the physiological activity, and data on the toxicity of these derivatives as well as examples of preparation for their administration are also disclosed.
The disclosed derivatives provide preventive and remedial effect for regressive disorders in the central nervous system including senile dementia of Alzheimer type.
21 Citations
16 Claims
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1. A pharmaceutical composition comprising:
a catechol represented by the formula (D) ##STR9## wherein R7 is a lower alkyl group, a catechol having the formula (E) ##STR10## wherein R8 is a lower alkyl group excluding a methyl group, or a catechol having the formula (F) ##STR11## wherein R9 is a C3-4 alkyl group, and a pharmaceutically acceptable carrier. - View Dependent Claims (8, 9, 10)
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2. A catechol having the formula (D):
- ##STR12## wherein R7 is a lower alkyl group.
- View Dependent Claims (5, 11, 12)
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3. A catechol having the formula (E):
- ##STR13## wherein R8 is a lower alkyl group excluding a methyl group.
- View Dependent Claims (6, 13, 14)
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4. A catechol having the formula (F):
- ##STR14## wherein R9 is a C3-4 alkyl group.
- View Dependent Claims (7, 15, 16)
Specification