Acetaminophen analogs, antigens, and antibodies
First Claim
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1. A compound of the formula:
- ##STR3## wherein;
R is an aliphatic linking group of from 1 to 12 carbon atoms;
Z is a group which linked to the carbonyl group, (CO), results in formation of an activated ester, which ester is capable of amide formation with an amino acid in an aqueous medium;
m is one; and
n is one.
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Accused Products
Abstract
Carbonyl derivatives of acetaminophen are provided for use in homogeneous enzyme immunoassays for acetaminophen. The derivatives are conjugated to antigenic substances for the preparation of antisera specific to acetaminophen, and to enzymes for the preparation of enzyme conjugates which compete with acetaminophen for antibody binding sites in a typical assay.
17 Citations
4 Claims
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1. A compound of the formula:
- ##STR3## wherein;
R is an aliphatic linking group of from 1 to 12 carbon atoms;Z is a group which linked to the carbonyl group, (CO), results in formation of an activated ester, which ester is capable of amide formation with an amino acid in an aqueous medium; m is one; and n is one. - View Dependent Claims (2, 3, 4)
- ##STR3## wherein;
Specification
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Current AssigneeDADE Behring Beteiligungs GmbH (Siemens AG)
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Original AssigneeSyntec Incorporated (Atos SE)
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InventorsKhanna, Pyare
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Primary Examiner(s)Elmore, Carolyn
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Application NumberUS07/080,503Time in Patent Office1,713 DaysField of Search548/542, 560/44, 560/887, 564/105US Class Current548/542CPC Class CodesG01N 33/531 Production of immunochemica...G01N 33/535 with enzyme label or co-enz...G01N 33/9486 Analgesics, e.g. opiates, a...
