Laser spectro-optic imaging for diagnosis and treatment of diseased tissue
First Claim
1. The method of destroying atheromatous plaque within an artery of a patient comprising the steps of initially administering to the patient a non-toxic atheroma-enhancing reagent which causes the plaque to have a characteristic optical property when illuminated with a given radiation, introducing a catheter system including fiberoptic cable means into the artery such that the distal end thereof is operatively opposite the plaque site, introducing into the proximal end of said fiberoptic cable means said given radiation, photoelectrically sensing at said proximal end said characteristic optical property to generate a control signal and under the control of said control signal transmitting via said cable means from said proximal end to said distal end, laser energy until said characteristic optical property is no longer sensed.
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Abstract
A laser catheter is disclosed wherein optical fibers carrying laser light are mounted in a catheter for insertion into an artery to provide controlled delivery of a laser beam for percutaneous intravascular laser treatment of atherosclerotic disease. A transparent protective shield is provided at the distal end of the catheter for mechanically diplacing intravascular blood and protecting the fibers from the intravascular contents, as well as protecting the patient in the event of failure of the fiber optics. Multiple optical fibers allow the selection of tissue that is to be removed. A computer controlled system automatically aligns fibers with the laser and controls exposure time. Spectroscopic diagnostics determine what tissue is to be removed.
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Citations
17 Claims
- 1. The method of destroying atheromatous plaque within an artery of a patient comprising the steps of initially administering to the patient a non-toxic atheroma-enhancing reagent which causes the plaque to have a characteristic optical property when illuminated with a given radiation, introducing a catheter system including fiberoptic cable means into the artery such that the distal end thereof is operatively opposite the plaque site, introducing into the proximal end of said fiberoptic cable means said given radiation, photoelectrically sensing at said proximal end said characteristic optical property to generate a control signal and under the control of said control signal transmitting via said cable means from said proximal end to said distal end, laser energy until said characteristic optical property is no longer sensed.
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5. The method of destroying atheromatous plaque within an artery of a patient, said plaque having a characteristic optical property when illuminated with a given radiation comprising the steps of introducing a catheter system including fiberoptic cable means into the artery such that the distal end thereof is operatively opposite the plaque site and the proximal external to the patient, introducing into the proximal end of said fiberoptic cable means said given radiation, photoelectrically sensing at said proximal end said characteristic optical property to generate a control signal and directly under the control of said control signal transmitting via said cable means from said proximal end to said distal end, laser energy until said characteristic optical property is no longer sensed.
- 6. The method of removing a selected portion of tissue from within an artery of a patient, the tissue having a characteristic optical property when illuminated with a given radiation comprising the steps of introducing a catheter system including a fiberoptic cable, the cable having a distal end and a proximal end, into the artery such that the distal end thereof is operatively opposite the selected portion of tissue and the proximal end external to the patient, introducing into the proximal end of said fiberoptic cable said given radiation, photoelectrically sensing at said proximal end said characteristic optical property to generate a control signal and in response to the control signal transmitting, via said cable from said proximal end to said distal end, laser energy until a selected change in the characteristic optical property is sensed.
- 10. A method of removing a selected portion of material from within an artery of a patient, the material having a characteristic optical property when illuminated with diagnostic radiation comprising the steps of introducing a catheter system including a fiber optic cable, the cable having a distal end and a proximal end, into the artery such that the distal end thereof is operatively opposite the selected portion of material and the proximal end external to the patient, introducing into the proximal end of said fiber optic cable said diagnostic radiation sensing at said proximal end said characteristic optical property with a spectral detector to generate a diagnostic signal, providing a control system to receive the diagnostic signal and comparing the diagnostic signal with a reference signal and in response to the comparison, selectively transmitting through said cable from said proximal end to said distal end, treatment laser energy to remove the selected portion of material.
Specification