Pyrogens separations by ceramic ultrafiltration

• US 5,104,546 A
• Filed: 07/03/1990
• Issued: 04/14/1992
• Est. Priority Date: 07/03/1990
• Status: Expired due to Term

• Current Assignee: Siemen Water Technologies Corporation (Siemens AG)
• Original Assignee: Aluminum Company of Egypt
• Inventors: Bhave, Ramesh R., Morgart, James R., Graaskamp, James M., Filson, James L.
• Primary Examiner(s): Dawson, Robert A.
• Assistant Examiner(s): FORTUNA, ANA M
• Application Number:
  US07/547,488
• Time in Patent Office: 651 Days
• Field of Search: 427/246, 427/244, 427/444, 210/252, 210/651, 210/500, 210/637, 210/490, 210/500.2, 210/23, 210/22, 210/323.2, 210/504, 210/510, 210/40, 210/694, 210/496, 210/767, 210/650, 210/653, 210/509, 423/626, 424/601, 424/450, 136/153, 117/66, 252/313, 264/45.5, 264/4.3
• US Class Current: 210/650
• CPC Class Codes: A61L 2/022 Filtration
• CPC Class Codes: B01D 2321/162 Use of acids
• CPC Class Codes: B01D 2321/164 Use of bases
• CPC Class Codes: B01D 65/02 Membrane cleaning or sterilisation ; Membrane regeneration
• CPC Class Codes: B01D 69/02 characterised by their properties
• CPC Class Codes: B01D 71/024 Oxides
• CPC Class Codes: C02F 1/444 by ultrafiltration or microfiltration
• CPC Class Codes: Y10S 210/90 Ultra pure water, e.g. conductivity water

Abstract

The method of the present invention for separating pyrogens includes passing a pyrogen-containing liquid through a zirconium oxide membrane on a ceramic support. The membrane on ceramic support preferably includes a porous sintered zircondium oxide membrane on alpha-alumina support.

Claims

1. A method of separating pyrogens comprising passing pyrogen-containing liquid through a zirconium oxide membrane on ceramic support, wherein said zirconium oxide membrane has a nominal pore size in the range of about 20Å

to 100Å

.

2. A method as set forth in claim 1 wherein said ceramic support comprises a porous sintered support.

3. A method as set forth in claim 2 wherein said support comprises a alpha-alumina.

4. A method as set forth in claim 3 wherein said zirconium oxide membrane has a nominal pore size less than or equal to about 50Å

.

5. A method as set forth in claim 4 wherein said passing pyrogen-containing liquid through a zirconium oxide membrane comprises a cross-flow or tangential flow over said membrane.

6. A method as set forth in claim 5 wherein pyrogens are separated in an amount of at least about a 5 log reduction.

7. A method as set forth in claim 5 wherein said pyrogens are separated to form a non-pyrogenic fluid.

8. A method as set forth in claim 5 further comprising an initial acid depyrogenating said membrane with nitric acid prior to passing said pyrogen-containing liquid.

9. A method as set forth in claim 8 wherein said liquid comprises water.

10. A method as set forth in claim 9 wherein said pyrogen-containing liquid comprises water containing pyrogen having a particle size of up to one micron.

11. A method as set forth in claim 10 wherein said pyrogens comprise a nominal molecular weight of about 10,000 to 20,000.

12. A method of purifying a liquid to remove pyrogens comprising passing pyrogen-containing liquid through a ceramic membrane having a nominal pore size in the range of about 20Å

to 100Å and

further having a flux rate or permeability higher than about 40 L/hr/m² / atm to remove pyrogens without substantial fouling of the membrane through a run time of at least 60 minutes.

13. A method as set forth in claim 12 wherein said ceramic membrane has a nominal pore size in the range of about 20Å

to 100Å

.

14. A method as set forth in claim 13 wherein said passing comprises a cross-flow or tangential filtration.

15. A method as set forth in claim 14 wherein said pyrogen separation comprises a 5 log reduction in pyrogens in said liquid.

16. A method as set forth in claim 14 wherein said pyrogen separation comprises forming a permeate of non-pyrogenic liquid.

17. A method as set forth in claim 16 wherein said liquid comprises water and said pyrogens comprise life sciences substances having molecular weights in the range of about 10,000 to 20,000.

18. A method of separating pyrogens comprising:

(a) providing an acid depyrogenated, ultrafiltration membrane of porous sintered zirconia oxide having a nominal pore size in the range of about 20Å

to 100Å

on alpha-alumina support by treating said membrane on support with nitric acid; and

(b) passing pyrogen-containing water by cross-flow or tangential filtration over and through said zirconia oxide membrane on alpha-alumina support to separate pyrogens and form a non-pyrogenic permeate.