Method of encapsulating biologically active substances with mucin, a capsule produced by the method, and a fodder containing such capsules

• US 5,104,662 A
• Filed: 10/16/1990
• Issued: 04/14/1992
• Est. Priority Date: 11/02/1989
• Status: Expired due to Fees

• Current Assignee: Valio Meijerien Keskusosuusliike
• Original Assignee: Valio Meijerien Keskusosuusliike
• Inventors: Nousiainen, Juha, Kalsta, Hannu, Setala, Jouko, Syvaoja, Eeva-Liisa
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): WEBMAN, EDWARD J
• Application Number:
  US07/598,222
• Time in Patent Office: 546 Days
• Field of Search: 424/451, 424/438, 424/442, 424/93, 424/551
• US Class Current: 424/451
• CPC Class Codes: A23K 10/18 of live microorganisms
• CPC Class Codes: A23K 20/189 Enzymes
• CPC Class Codes: A23K 40/30 by encapsulating; by coating
• CPC Class Codes: A61K 9/1652 Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin homeopathic globules A61K9/1623
• CPC Class Codes: A61K 9/1664 Compounds of unknown constitution, e.g. material from plants or animals oils, fats, waxes, shellac A61K9/1617

Abstract

The invention relates to a method of encapsulating biologically active substances by gelling them with intestinal mucus (mucin). The invention is also concerned with a capsule produced by the method, its use as a fodder admixture, and a fodder containing such capsules.

Claims

1. A method for encapsulating biologically active substances, comprising adding intestinal mucus in an amount effective for gelling the biologically active substances.

2. A method according to claim 1, wherein the gelling is carried out in the presence of alginate and calcium ions.

3. A method of claim 1, wherein the biologically active substances are micro-organisms or biologically active components thereof.

4. A method according to claim 3, wherein the micro-organisms are lactic acid bacteria.

5. A method according to claim 1, wherein the biologically active substances are enzymes.

15. A method according to claim 1, wherein the biologically active substances are antibiotics.

16. A method according to claim 1 wherein the biologically active substances are antibodies.

17. A method according to claim 1 wherein the biologically active substances are enzymes.

6. A capsule comprising intestinal mucus and biologically active substances gelled with said mucus.

7. A capsule according to claim 6, wherein the biologically active substances are micro-organisms.

8. A capsule according to claim 7, wherein the micro-organisms are lactic acid bacteria.

9. A method which comprises using a capsule of intestinal mucus containing biologically active substances in a fodder admixture.

10. A method according to claim 9, wherein the biologically active substances are micro-organisms.

14. A method according to claim 10 wherein the micro-organisms are lactic acid bacteria.

11. Fodder comprising a capsule of intestinal mucus containing biologically active substances.

12. Fodder according to claim 11, wherein the biologically active substances are micro-organisms.

13. Fodder according to claim 12 wherein the micro-organisms are lactic acid bacteria.