Microdialysis probe

• US 5,106,365 A
• Filed: 06/15/1990
• Issued: 04/21/1992
• Est. Priority Date: 06/16/1989
• Status: Expired due to Fees

• Current Assignee: Europhor SA
• Original Assignee: Europhor SA
• Inventors: Hernandez, Luis
• Primary Examiner(s): Grieb, William H.
• Application Number:
  US07/539,073
• Time in Patent Office: 676 Days
• Field of Search: 604/27, 604/29, 128/632, 128/760
• US Class Current: 604/27
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14528 invasively
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement

Abstract

A microdialysis probe comprising an outer sleeve containing tubes for delivering and removing dialysis products. The dialysis membrane is directly fixed to the end edge of the outer sleeve by gluing the membrane in such a manner as to avoid extra thickness at the junction between the membrane and the sleeve.

Claims

1. A microdialysis probe, comprising an outer sleeve having a proximal end region and a distal end region and a transverse seal at said proximal end region, a plurality of tubes extending into said outer sleeve through said seal for delivering and removing dialysis products, said outer sleeve at said distal end region thereof being provided with a circumferential chamfer, and a dialysis membrane cemented to said outer sleeve at said circumferential chamfer of the latter.

2. A microdialysis probe according to claim 1, wherein said circumferential chamfer is directed inwardly of said outer sleeve, said dialysis membrane has the form of a disc with an outwardly directed peripheral chamfer, and said dialysis membrane is located within the confines of said distal end region of said outer sleeve with said peripheral chamfer of the former juxtaposed and cemented to said circumferential chamfer of the latter.

3. A microdialysis probe according to claim 1, wherein said circumferential chamfer is directed outwardly of said outer sleeve, said dialysis membrane has the form of a tube having first and second end regions, and said distal end region of said outer sleeve is received within said first end region of said dialysis membrane, the portion of the interior surface of said dialysis membrane at said first end region thereof which is juxtaposed to said circumferential chamfer of said outer sleeve being cemented to the latter along said circumferential chamfer, and said dialysis membrane being sealed at said second end region thereof.

4. A microdialysis probe, comprising an outer sleeve having a proximal end region and a distal end region and a transverse seal at said proximal end region, a plurality of tubes extending into said outer sleeve through said seal for delivering and removing dialysis products, said outer sleeve at said distal end region thereof being provided with an outwardly directed circumferential chamfer, and a tubular dialysis membrane having first and second end regions and secured to said outer sleeve at said distal end region of the latter, said distal end region of said outer sleeve being received in said first end region of said tubular dialysis membrane with a tight fit, and said tubular dialysis membrane being sealed at said second end region thereof.

5. A microdialysis probe according to claim 4, wherein said outer sleeve is made of flexible plastic material.