Analytical test device and the use thereof
First Claim
1. An analytical device for the quantitative and qualitative determination of an analyte in a liquid test sample, said analytical device comprising:
- a) a base means;
b) a porous member received in said base means;
c) at least one analyte responsive substance which undergoes a detectable response to the presence and concentration of analyte dispersed throughout said porous member;
d) a reaction component;
e) a cover means integral with said base means permanently affixed in a superimposed spaced relationship thereto;
f) a reaction well in said cover means for storing said reaction component and adapted to receive liquid test sample whereby said liquid test sample and said reaction component form a liquid reaction mixture within said reaction well;
g) passage means in said reaction well for transferring said reaction mixture therethrough, said passage means normally being in a spaced superimposed relationship to said porous member and effectively closed to transfer therethrough of said reaction mixture, and said passage means being selectively movable toward said porous member to effectively open to passage therethrough of said reaction mixture to said porous member whereby said analyte responsive substance will undergo a detectable response to said analyte present in said liquid reaction mixture; and
h) said base means provided with an observation port exposing said porous member for observing any detectable response of said analyte responsive substance;
i) wherein said cover means includes a central portion, said reaction well positioned within said central portion and deflective means in the form of a deformable circumferential corrugation around said central portion integral with said center portion and said cover means to impart flexibility of said central portion in said cover means so that said central portion may be displaced towards said porous member.
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Accused Products
Abstract
The analytical device includes a base adapted to support a porous member having dispersed throughout at least one analyte responsive substance which undergoes a detectable response to the presence and concentration of the analyte in the test sample. A cover integral with the base is provided with a reaction well adapted for storing a dried reaction component and for receiving the liquid test sample deposited on the analytical device whereby the liquid test sample and the reaction component form a liquid reaction mixture therein. A passage is included in the reaction well for selectively transferring the reaction mixture therethrough. This passage is normally spaced from the porous member and effectively closed to transfer therethrough of the reaction mixture, and is selectively movable toward the porous member to effectively open to passage therethrough of the reaction mixture whereby the analyte responsive substance will undergo a detectable response to the analyte present in the liquid reaction mixture. The base is provided with a suitable viewing port to permit monitoring of the detectable response generated as a result of the at least one analyte responsive substance interacting with the analyte in the test sample. Such a detectable response may be detected by appropriate photometric or colorimetric apparatus.
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Citations
9 Claims
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1. An analytical device for the quantitative and qualitative determination of an analyte in a liquid test sample, said analytical device comprising:
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a) a base means; b) a porous member received in said base means; c) at least one analyte responsive substance which undergoes a detectable response to the presence and concentration of analyte dispersed throughout said porous member; d) a reaction component; e) a cover means integral with said base means permanently affixed in a superimposed spaced relationship thereto; f) a reaction well in said cover means for storing said reaction component and adapted to receive liquid test sample whereby said liquid test sample and said reaction component form a liquid reaction mixture within said reaction well; g) passage means in said reaction well for transferring said reaction mixture therethrough, said passage means normally being in a spaced superimposed relationship to said porous member and effectively closed to transfer therethrough of said reaction mixture, and said passage means being selectively movable toward said porous member to effectively open to passage therethrough of said reaction mixture to said porous member whereby said analyte responsive substance will undergo a detectable response to said analyte present in said liquid reaction mixture; and h) said base means provided with an observation port exposing said porous member for observing any detectable response of said analyte responsive substance; i) wherein said cover means includes a central portion, said reaction well positioned within said central portion and deflective means in the form of a deformable circumferential corrugation around said central portion integral with said center portion and said cover means to impart flexibility of said central portion in said cover means so that said central portion may be displaced towards said porous member. - View Dependent Claims (2, 3, 4, 5)
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6. An analytical device for the quantitative and qualitative determination of an analyte in a liquid test sample, said analytical device comprising:
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a) a base means; b) a porous member received in said base means; c) at least one analyte responsive substance which undergoes a detectable response to the presence and concentration of analyte dispersed throughout said porous member; d) a reaction component; e) a cover means integral with said base means permanently affixed in a superimposed spaced relationship thereto; f) a reaction well in said cover means for storing said reaction component and adapted to receive liquid test sample whereby said liquid test sample and said reaction component form a liquid reaction mixture within said reaction well; g) passage means in said reaction well for transferring said reaction mixture therethrough, said passage means normally being in a spaced superimposed relationship to aid porous member and effectively closed to transfer therethrough of said reaction mixture, and said passage means being selectively movable toward said porous member to effectively open to passage therethrough of said reaction mixture to said porous member whereby said analyte responsive substance will undergo a detectable response to said analyte present in said liquid reaction mixture; and h) said base means provided with an observation port exposing said porous member for observing any detectable response of said analyte responsive substance; i) wherein said reaction well is a cylindrical depression in said cover means and said passage means includes a projection centrally positioned within said cylindrical depression and at least two support arms extending from said projection to said reaction well defining openings therebetween. - View Dependent Claims (7)
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8. An analytical device for the quantitative and qualitative determination of an analyte in a liquid test sample, said analytical device comprising:
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a) a base means; b) a porous member received in said base means; c) at least one analyte responsive substance which undergoes a detectable response to the presence and concentration of analyte dispersed throughout said porous member; d) a reaction component; e) a cover means integral with said base means permanently affixed in a superimposed spaced relationship thereto; f) a reaction well in said cover means for storing said reaction component and adapted to receive liquid test sample whereby said liquid test sample and said reaction component form a liquid reaction mixture within said reaction well; g) passage mans in said reaction well for transferring said reaction mixture therethrough, said passage means normally being in a spaced superimposed relationship to said porous member and effectively closed to transfer therethrough of said reaction mixture, and said passage means being selectively movable toward said porous member to effectively open to passage therethrough of said reaction mixture to said porous member whereby said analyte responsive substance will undergo a detectable response to said analyte present in said liquid reaction mixture; and h) said base means provided with an observation port exposing said porous member for observing any detectable response of said analyte responsive substance; i) wherein said reaction well is a cylindrical depression in said cover means and said passage means includes a projection centrally positioned within said cylindrical depression and a transverse wall extending from said projection to said reaction well and having openings therein normally substantially closed to fluid passage therethrough. - View Dependent Claims (9)
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Specification