Pressure responsive multiple input infusion system

• US 5,108,367 A
• Filed: 04/08/1991
• Issued: 04/28/1992
• Est. Priority Date: 02/08/1984
• Status: Expired due to Term

• Current Assignee: Hospira Incorporated (Pfizer Inc.)
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Strohl, Clair, Epstein, Paul, LaWhite, Eric, Coyne, Henry, Petschek, Harry, Kaleskas, Edward, Adaniva, George
• Primary Examiner(s): Yasko, John D.
• Assistant Examiner(s): CERMAK, ADAM
• Application Number:
  US07/682,871
• Time in Patent Office: 386 Days
• Field of Search: 128/DIG. 12, 128/DIG. 13, 604/56, 604/65-67, 604/80, 604/82, 604/118, 604/121-123, 604/153, 604/250, 604/256, 604/258, 417/479, 417/474, 417/413
• US Class Current: 604/67
• CPC Class Codes: A61M 2005/1402 Priming
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 5/14224 Diaphragm type
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: Y10S 128/12 Pressure infusion

Abstract

An infusion system for administering multiple infusates at individually programmable rates, volumes, and sequences in any order from any one or more of plural fluid input ports through a patient output port and into the circulatory system of a patient. Infusates may be either continuously or time sequentially administered, and infusates may be either intermittently administered at selectively regular intervals or in time overlap to administer a dilution. Various error conditions are automatically detected and alarms generated in the event of conflicts between infusates, to identify times of no infusions, and to identify system malfunctions. The system is selectively operable, among others, in a priming mode, a maintenance mode, a normal-on mode, and a manual override mode. The system is operative to adapt actual to desired flow rates in normal operation. All fluids flow through a unitary disposable cassette without making any other system contact. Air bubbles in the fluid line are automatically detected and disposed of. Fluid pressures are monitored and system operation adjusted as a function of such pressures. Infusates may be administered from syringes as well as from standard bag or bottle containers. Infusate from a selected input port may be controllably pumped into a syringe for unsticking the syringe plunger. The system is selectively operable to adjust total fluid volume and rate to below preselected values for patients whose total intake must be restricted. The system is operable to maintain an accurate record of total infusion history.

Claims

1. An infusion system having plural fluid input ports and a fluid output port, comprising:

a fluid manifold having;

a fluid flow channel,

plural fluid input valves each connected to a corresponding one of said plural fluid input ports,

a patient output valve connected to said fluid output port and in fluid communication with said plurality of fluid input valves via said fluid flow channel,

means, in fluid communication via said fluid flow channel with said plurality of fluid input valves and said fluid output valve, for pumping fluid from any input port through said output port, and

a pressure chamber in fluid communication with said plural fluid input valves and disposed intermediate and in fluid communication with said pumping means and said fluid output valve via said fluid flow channel, said pressure chamber interposed within and formed discretely from said fluid flow channel;

a system controller having memory;

means coupled to said system controller for writing into said memory first data representative of a desired course of infusion including at least one of time sequence of fluid to be administered from any one or more of said fluid input ports, rate of fluid to be administered from corresponding ones of said any one or more of said fluid input ports, and a duration of fluid to be administered from corresponding ones of said any one or more of said fluid input ports;

a pressure transducer operatively connected to said pressure chamber and coupled to said system controller for providing second data representative of the pressure in said fluid manifold at any of said input valves, said pumping means, and said output valve; and

means coupled to said system controller and to said fluid manifold and operative in response to said first and second data for selectively actuating individual ones of said fluid input valves in dependence on said first data to admit a selected fluid into said fluid manifold and for both selectively actuating said output valve, and said pumping means in dependence on said first and second data.

2. The invention of claim 1, wherein said manifold further includes a vent output port and an associated valve that is in fluid communication with said plural fluid input valves.

3. The invention of claim 2, wherein said system controller is selectively operable to control administration of fluid from any selected one of said plural fluid input ports through said manifold and out said vent port to flush the manifold of any air therein to prevent air embolism.

4. The invention of claim 3, wherein said system controller is operative to control pumping of fluid from any selected one of said plural fluid input ports through said manifold and out said vent port.

5. The invention of claim 3, wherein said system controller is operative to control flow of fluid by gravity head from said selected one of said plural fluid input ports through said manifold and out said vent port.

6. The invention of claim 1, wherein said fluid manifold includes a cassette having first and second mating housing portions, one of said housing portions defining a pumping chamber, and further includes a flexible diaphragm sandwiched therebetween defining a pumping diaphragm adjacent said pumping chamber and a plurality of valve pads defining corresponding ones of said fluid input valves and said output valve.

7. The invention of claim 6, wherein said pumping diaphragm is dome shaped.

8. The invention of claim 6, wherein said pumping means includes a plurality of plungers individually mounted for reciprocating motion, and a first stepper motor driven cam mounted for driving the plungers against and away from the corresponding input and output valve pads, and further includes a pumping piston mounted for reciprocating motion, and a second stepper motor driven cam mounted for controllably driving the pumping piston into and out of the pumping chamber.

9. An infusion system having plural fluid input ports and a fluid output port, comprising:

a fluid manifold having plural fluid input valves each connected to a corresponding one of said plural fluid input ports, a patient output valve connected to said fluid output port and in fluid communication with said plurality of fluid input valves, and means in fluid communication with said plural fluid input valves and said fluid output valve for pumping fluid from any input port through said output port;

a system controller having memory, a processor to provide system I/O and pump control, and a pump processor slaved to said I/O and pump control processor via a communication link;

means coupled to said system controller for writing into said memory first data representative of a desired course of infusion including at least one of time sequence of fluid to be administered from any one or more of said fluid input ports, rate of fluid to be administered from corresponding ones of said any one or more of said fluid input ports, and a duration of fluid to be administered from corresponding ones of said any one or more of said fluid input ports;

a pressure transducer coupled to said system controller and to said fluid manifold for providing second data representative of the pressure in said fluid manifold; and

means coupled to said system controller and to said fluid manifold and operative in response to said first and second data for selectively actuating individual ones of said fluid input valves in dependence on said first data to admit a selected fluid into said fluid manifold and for both selectively actuating said output valve, and said pumping means in dependence on said first and second data.

10. The invention of claim 9, wherein said writing means includes an operator interactive display and an operator keyboard having a plurality of function and data keys, said display and said keyboard being coupled to said system I/O and pump control processor.

11. The invention of claim 9, wherein said pressure transducer is operatively connected to said pump control processor, and said pump control processor is operative to read said pressure transducer to obtain data representative of pressure of at least one of corresponding fluid input ports, of pressure in the fluid output port, and of air in the fluid manifold.