Dispensing devices powered by lyotropic liquid crystals
First Claim
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1. A dispensing device which comprises:
- (a) a mixture comprising a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and
(b) a coating containing a plurality of pores which coating surrounds the mixture.
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Abstract
This invention relates to devices useful for the controlled delivery of one or more beneficial agents to an environment of use. More specifically, this invention concerns such devices which are powered by lyotropic liquid crystals. This invention also relates to the controlled delivery of one or more beneficial agents to an aqueous environment of use through the use of such lyotropic liquid crystal powered dispensing devices. Also disclosed are methods for the controlled delivery of one or more beneficial agents to an aqueous environment of use which comprise administering to or otherwise placing the devices of this invention in the environment of use.
53 Citations
46 Claims
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1. A dispensing device which comprises:
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(a) a mixture comprising a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and (b) a coating containing a plurality of pores which coating surrounds the mixture. - View Dependent Claims (2, 3, 4, 5, 6, 7, 40)
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8. A dispensing device which comprises:
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(a) a mixture comprising a beneficial agents and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and (b) a coating which surrounds the mixture and which comprises a polymer and one or more porosigens. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 41, 46)
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21. A dispensing device which comprises:
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(a) a first layer comprising a mixture of a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and (b) a second layer comprising a lyotropic liquid crystal which second layer is adjacent to the first layer and comprises an area in contact with the first layer; and (c) a coating containing at least one hole adjacent to the first layer which coating surrounds the first and second layers except for said area in contact. - View Dependent Claims (22, 23, 24, 25, 42)
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26. A dispensing device which comprises:
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(a) a mixture comprising a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and (b) a coating containing a least one hole which coating surrounds the mixture. - View Dependent Claims (27, 28, 29, 30, 31, 43)
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32. A dispensing device which comprises:
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(a) a first layer comprising a mixture of a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and (b) a second layer comprising a lyotropic liquid crystal which second layer is adjacent to the first layer and comprising an area in contact with the first layer; and (c) a coating containing a plurality of pores which coating surrounds the first and second layers except for said area in contact. - View Dependent Claims (33, 34, 35, 44)
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36. A dispensing device which comprises:
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(a) a first layer comprising a mixture of a beneficial agent and a lyotropic liquid crystal selected from the group consisting of a phospholipid, a glycolipid, a salt of a fatty acid, a half-ionized fatty acid-salt and mixtures thereof; and (b) a second layer comprising a lyotropic liquid crystal which second layer is adjacent to the first layer and comprises an area in contact with the first layer; and (c) a coating which surrounds the first and second layers except for said area in contact and which comprises a polymer and one or more porosigens. - View Dependent Claims (37, 38, 39, 45)
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Specification