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Endothelial envelopment drug carriers

  • US 5,108,759 A
  • Filed: 12/08/1989
  • Issued: 04/28/1992
  • Est. Priority Date: 04/01/1987
  • Status: Expired due to Fees
First Claim
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1. A composition comprising a multivalent binding agent surface which binds determinants of endothelial or epithelial cells;

  • wherein the composition is a microsphere, microaggregate, or macromolecule less than about 250 micrometers in size, and has a matrix capable of containing a drug or diagnostic agent at a content of at least 12% (w/w); and

    wherein the multivalent binding agent surface consists of carbohydrate, oligosaccharide, monosaccharide, negatively charged polysaccharide, negatively charged oligosaccharide, dextran sulfate, glycosaminoglycan, heparin, heparin fragment, synthetic heparin analogue, heparan sulfate, dermatan sulfate, chondroitin sulfate, hyaluronic acid; and

    which induces rapid partial or total envelopment of said composition by endothelial or epithelial cells and facilitated migration across said cells into proximal tissues.

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