Method of predisposing mammals to accelerated tissue repair

• US 5,108,989 A
• Filed: 04/04/1990
• Issued: 04/28/1992
• Est. Priority Date: 04/04/1990
• Status: Expired due to Term

• Current Assignee: Genentech, Inc. (Roche Holding AG)
• Original Assignee: Genentech, Inc. (Roche Holding AG)
• Inventors: Beck, L. Steven, Amento, Edward P.
• Primary Examiner(s): Schain, Howard E.
• Assistant Examiner(s): KOH, CHOON P
• Application Number:
  US07/504,495
• Time in Patent Office: 755 Days
• Field of Search: 514/12, 514/21
• US Class Current: 514/8.9
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07K 14/495 Transforming growth factor [TGF]

Abstract

A method of predisposing a mammal to accelerated tissue repair is provided. This method comprises systemically administering to the mammal, prior to its exposure to tissue damage, an effective amount of TGF-β. Preferably, the TGF-β is administered no more than about 24 hours prior to exposure to tissue damage.

Claims

1. A method of predisposing a mammal to accelerated tissue repair comprising systematically administering to the mammal, within a time range of from about 24 hours to greater than about 5 minutes prior to tissue damage exposure, an effective amount of TGF-β

.

2. The method of claim 1 wherein the administration is in a single dose.

3. The method of claim 1 wherein the administration is intravenous.

4. The method of claim 1 wherein the TGF-β

is human TGF-β

.

5. The method of claim 4, wherein the TGF-β

is TGF-β

1.

6. The method of claim 1 wherein the mammal is human.

7. The method of claim 1 wherein the tissue repair is wound healing and the tissue damage is a wound.

8. The method of claim 1 wherein the tissue repair is bone repair and the tissue damage is a bone fracture, prosthetic implant, or bony defect.

9. The method of claim 1 wherein the tissue damage is surgical incision.