Artificial pancreas

• US 5,109,866 A
• Filed: 03/21/1990
• Issued: 05/05/1992
• Est. Priority Date: 07/21/1988
• Status: Expired due to Fees

• Current Assignee: Societe D'Applications Des Techniques Photoniques
• Original Assignee: Societe D'Applications Des Techniques Photoniques
• Inventors: Rouyer, Philippe, Gy, Jules, Guegan, Alain, Hespel, Jean-Pierre
• Primary Examiner(s): Pellegrino, Stephen C.
• Assistant Examiner(s): Shumaker, Steven J.
• Application Number:
  US07/490,610
• Time in Patent Office: 776 Days
• Field of Search: 604/27--31, 604/48-53, 604/65-67, 604/246, 128/632, 128/633, 128/636, 128/637, 128/664, 128/665, 128/771, 128/DIG. 13, 364/413.07, 364/413.09, 422/63-65, 422/68.1
• US Class Current: 600/368
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/155 Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals devices loaded with multiple lancets simultaneously A61B5/15146
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G01N 2035/00039 Transport arrangements specific to flat sample substrates, e.g. pusher blade
• CPC Class Codes: G01N 2035/00089 Magazines
• CPC Class Codes: G01N 2035/00108 Test strips, e.g. paper
• CPC Class Codes: G01N 35/00029 provided with flat sample substrates, e.g. slides G01N35/028 takes precedence

Abstract

The artificial pancreas comprises a unit for automatic and periodical withdrawal of blood samples from the body of a patient (M), a unit for measuring the glycemia of this sample, a unit (8) for injecting insulin or glucose, and a unit (U) for calculation and data processing in order to determine the amount of insulin or glucose which is to be administered to the patient as a function of the glucose level measured by the measurement unit, and to control consequently the injection unit (8). This artificial pancreas is characterized in that the measurement of the glycemia is effected by reading the color of a strip reacting to glycemia, the measurement unit comprising to this effect: a) a strip distribution station (3); b) a station (4) for depositing a blood droplet on the strip; c) a station (5) for wiping the strip; d) a station (6) for optical reading of the color taken by the strip; e) a station (7) for removing the strip; f) a transportation device (1, 2) for conveying the strips individually from station to station.

Claims

1. Artificial pancreas of the type comprising a means for automatically and periodically withdrawing blood samples from the body of a patient (M), means for measuring a level of glucose present in the blood sample (glycemia), means (8) for injecting a dose of insulin or glucose into the body of a patient, and means (u) for calculating and data processing which determines an amount of insulin or glucose to be administered to the patient as a function of the glucose level measured by the measuring means and for controlling the injecting means (8) in a manner corresponding to the amount of insulin or glucose to be administered, characterized in that measurement of glycemia is carried out by reading a color of a reactive zone (z) of a strip (b) reactive to glycemia, the measuring means comprising to this effect:

a) means (3) for distributing strips (b);

b) means (4) for depositing a blood droplet supplied by said withdrawing means on the reactive zone (z) of a strip (b);

c) means (5) for wiping the zone (z);

d) means (6) for optical reading of the color taken by the zone (z);

e) means (7) for removing the strip; and

f) means (1,

     2) for automatically conveying the strips (b) individually from means to means (3, 4, 5, 6,

     7), wherein said measuring means is mounted on a common deck (100).

2. Artificial pancreas according to claim 1, characterized in that the means for conveying comprises a pincer (2) having an upper jaw (23) and a lower jaw (25) articulated about an axis (26), said jaws (23, 25) being designed to grip and retain a strip (b), said pincer (2) being movably mounted for translation along a substantially horizontal axis (X--X'"'"') in a rotary turret (10) rotatable about a vertical axis (Z--Z'"'"').

3. Artificial pancreas according to claim 2, characterized in that the upper jaw (23) of said pincer (2) is provided with a small elastic tongue (24) for blocking the strip (b).

4. Artificial pancreas according to claim 2, characterized in that the closure of the pincer (2) being normally ensured by contact between a portion of the lower jaw (25) and a portion of the common deck (100) of the measuring means.

5. Artificial pancreas according to claim 4, characterized in that the means (7) for removing the strip comprises an inclined plate (70) provided with a small tongue (72) for retaining the strip (b), the plate (70) being arranged in the proximity of an opening (101) made in the common deck (100), said opening causing the pincer (2) to open by means of the swinging of the lower jaw (25) and permitting the passage of the removed strips (b'"'"').

6. Artificial pancreas according to claim 1, characterized in that the strip distributing means (3) comprises a container (30) in which the strips (b) are positioned horizontally in a vertical stack under a certain pressure, a rotary drive knurled wheel (33) provided level with the base (31) of the container and being designed to remove from the container (30), through an opening (32), a strip adjacent to said opening.

7. Artificial pancreas according to claim 1, characterized in that the depositing means (4) comprises a support plate (40) passed through by a small conduit (42) for delivery of the blood droplet, an element (43), for supporting the strip, arranged under said small conduit (42) and wherein said small conduit is coupled to said withdrawing means (C1,P).

8. Artificial pancreas according to claim 1, characterized in that the wiping means (5) comprises a frame (51) equipped with a pair of reels (50, 50'"'"') for distributing and receiving, respectively, a band of absorbent paper (57), means being provided for driving at least one (50'"'"') of the reels in rotation, and means for supporting (52) the zone (z) adjacent to said band of absorbent paper (57) and means for selectively pressing (55) the zone (z) into engagement with said band of absorbent paper (57).

9. Artificial pancreas according to claim 8, wherein the means for supporting (52) comprises a lower pressing block (52) and the means for selectively pressing (55) comprises an upper pressing block (55), characterized in that said band (57) is guided by rollers (56, 56'"'"') so as to pass between the lower pressing block (52), and the upper pressing block (55), between which the reactive zone of the strip takes up a position.

10. Artificial pancreas according to claim 9, characterized in that said band (57) and the upper pressing block (55) are borne by a plate (53) which is articulated on the frame (51) about a horizontal axis (500'"'"'), said plate (53) being integral with a cam (54) for cooperating with a control member (27) equipped on the pincer (2) for temporary lifting of the upper block (55) and the band (57) during the positioning of the reactive zone of the strip between the two blocks (52-55) and during withdrawal of the strip.

11. Artificial pancreas according to claim 1, characterized in that the means (6) for optical reading of the color taken by the reactive zone (z) of the strip (b) comprises a reading casing (62) provided with a slot (64) turned towards the means for conveying (1, 2) and oriented in such a way as to be aligned with the strip (b).