New organoboron reagents for the preparation unsubstituted propargylic alcohols
First Claim
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1. A compound of the formula ##STR4## wherein R, R1 and R2 are each independently selected from a group represented by C1 -C6 alkyl or phenyl.
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Abstract
The novel organoboron reagent of the present invention is useful in the preparation of unsubstituted propargylic alcohols. This compound reacts with aldehydes and ketones cleanly to afford propargylic alcohols in excellent yields. Unsubstituted propargylic alcohols are important synthetic intermediates in the synthesis of a number of natural products. In addition, the novel organoboron reagent of the present invention also demonstrates diastereomeric selectivity when reacted with enatiomerically pure aldehydes.
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2 Claims
- 1. A compound of the formula ##STR4## wherein R, R1 and R2 are each independently selected from a group represented by C1 -C6 alkyl or phenyl.
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Current AssigneeMerrell Pharmaceuticals Incorporated (Dow, Inc.)
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Original AssigneeMerrell Pharmaceuticals Incorporated (Dow, Inc.)
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InventorsGoralski, Christian T., Evans, Jonathan C.
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Primary Examiner(s)Shaver, Paul F.
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Application NumberUS07/717,970Time in Patent Office320 DaysField of Search556/403US Class Current556/403CPC Class CodesC07F 7/0803 Compounds with Si-C or Si-S...
