Method and apparatus for cardioverter/pacer utilizing neurosensing

• US 5,111,815 A
• Filed: 10/15/1990
• Issued: 05/12/1992
• Est. Priority Date: 10/15/1990
• Status: Expired due to Term

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Mower, Morton M.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Getzow, Scott M.
• Application Number:
  US07/597,378
• Time in Patent Office: 575 Days
• Field of Search: 128/419 PG, 128/419 C, 128/419 D
• US Class Current: 607/4
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585

Abstract

A method and apparatus for cardioverter/pacemaking utilizing neurosensing. The invention utilizes the baroreceptor nerves found in the body. A neurosense electrode is placed around the carotid sinus nerve and a sense amplifier with automatic gain control and an integral band pass filter provides a frequency-to-voltage converter with a frequency proportional to the stimulus received from the carotid sinus nerve. The voltage from the frequency-to-voltage converter is sent to the analog-to-digital converter where it is bussed to a microprocessor. The microprocessor then drives a pacing lead and in the presence of a cardiac signal the microprocessor provides a cardioverting signal to the cardioverting lead if ventricular arrhythmia is sensed. The microprocessor also drives a telemetry coil and receives ventricular information from the ventricular sensing lead.

Claims

1. A programmable baroreceptor nerve sensing based cardioverter and pacemaker apparatus comprising:

(a) a neurosense electrode having a neurosignal output wherein the neurosense electrode is in contact with a sensed nerve and provides a neurosignal thereon;

(b) a neurosense amplifier having an automatic gain control and band pass filter including an input connected to the neurosignal output wherein the neurosense amplifier further has an output and provides an amplified neurosignal thereon;

(c) a frequency-to-voltage converter having a first input connected to the neurosense amplifier output wherein the frequency-to-voltage converter has an output and provides a voltage converted signal thereon proportional to the frequency of the amplified neurosignal;

(d) an analog-to-digital converter including an input connected to the frequency-to-voltage converter output wherein the analog-to-digital converter has an output and provides a digital signal representative of the voltage converted signal thereon; and

(e) a microprocessor for executing a pressure responsive control algorithm in response to the representative digital signal including an input connected to the analog-to-digital converter output wherein the microprocessor has an input/output port, an output for providing pacing signals according to the control algorithms and a second output for providing defibrillation signals according to the control algorithm.

2. The apparatus of claim 1 wherein the neurosense electrode comprises a set of two coils surrounding the sensed nerve.

3. The apparatus of claim 1 wherein the neurosense electrode is comprised of a spiral wound coil.

4. The apparatus of claim 1 wherein the microprocessor receives 8 bits of data from the analog-to-digital converter.

5. The apparatus of claim 1 wherein the sense amplifier with automatic gain control and band pass filter passes analog signals in the frequency range of 300 to 5,000 Hertz.

6. The apparatus of claim 1 wherein the sensed nerve comprises the carotid sinus nerve.

7. The apparatus of claim 1 wherein the sensed nerve comprises the vagus nerve.

8. The apparatus of claim 1 wherein the sensed nerve comprises the sympathetic cardiac nerve.

9. The apparatus of claim 1 wherein the sensed nerve comprises the sympathetic basal constrictor nerves.

10. The apparatus of claim 1 wherein the microprocessor also outputs a cardiac pacing signal.

11. The apparatus of claim 10 wherein the microprocessor also outputs a cardioverting signal.

12. The apparatus of claim 1 further comprising a means for ventricular sensing with a first output connected to the first input of the microprocessor.

13. A programmable baroreceptor nerve sensing based cardioverter and pacemaker apparatus comprising:

(a) means for sensing neurosignals having a neurosignal output;

(b) means for amplifying neurosense signals including an automatic gain control and band pass filter having an input connected to the neurosignal output wherein the neurosense amplifier means has an output for providing amplified neurosense signals;

(c) means for converting frequency to voltage having an input connected to the output of the neurosense amplifier means wherein the frequency-to-voltage converter means has an output and wherein the amplified neurosense signals are converted to converted analog signals having voltage amplitudes proportional to the frequency of the amplified neurosense signals at the converter output;

(d) means for converting analog signals to digital signals having an input connected to the converter output of the frequency-to-voltage converter means wherein the analog-to-digital converter means has an A/D output for providing digital signals proportional to the converted analog signals; and

(e) microprocessor means for executing a pressure responsive control algorithm with a first input connected tot he A/D output of the analog-to-digital converter means wherein the microprocessor means includes an input/output port, a first output for providing a cardiac pacing signal according to the control algorithm, and a second output for providing a cardioverting signal according to the control algorithm, wherein the control algorithm executes in response to the digital signals on the A/D output.

14. The apparatus of claim 13 wherein the neurosensing means comprises a set of two coils surrounding a sensed nerve.

15. The apparatus of claim 14 wherein the neurosensing means is comprised of a spiral wound coil.

16. The apparatus of claim 14 wherein the sensed nerve comprises the carotid sinus nerve.

17. The apparatus of claim 14 wherein the sensed nerve comprises the vagus nerve.

18. The apparatus of claim 14 wherein the sensed nerve comprises the sympathetic cardiac nerve.

19. The apparatus of claim 14 wherein the sensed nerve comprises the sympathetic basal constrictor nerves.

20. The apparatus of claim 13 wherein the digital signal comprises 8 bits of data from the analog-to-digital converter.

21. The apparatus of claim 13 wherein the sense amplifier means with automatic gain control and band pass filter passes analog signals in the frequency range from 300-5,000 Hertz.

22. The apparatus of claim 13 further including a telemetry means including an input/output port connected to the microprocessor input/output port.

23. A method for operating a pacemaker apparatus comprising the steps of:

(a) sensing neurosignals from a baroreceptor nerve;

(b) processing the sensed neurosignals and producing a cardioverting control signal in response to the sensed neurosignals; and

(c) operating the pacemaker to produce cardioverting signals in response to the cardioverting control signal.