Process for producing hydroxylated plasma-polymerized films and the use of the films for enhancing the compatiblity of biomedical implants

• US 5,112,457 A
• Filed: 07/23/1990
• Issued: 05/12/1992
• Est. Priority Date: 07/23/1990
• Status: Expired due to Fees

• Current Assignee: Case Western Reserve University
• Original Assignee: Case Western Reserve University
• Inventors: Marchant, Roger E.
• Primary Examiner(s): Niebling, John F.
• Assistant Examiner(s): MARQUIS, STEVEN
• Application Number:
  US07/556,740
• Time in Patent Office: 659 Days
• Field of Search: 525/329.6, 525/337, 525/366, 525/367, 204/165
• US Class Current: 204/165
• CPC Class Codes: A61L 33/0088 by grafting of a monomer onto the substrate
• CPC Class Codes: C08F 26/10 N-Vinyl-pyrrolidone
• CPC Class Codes: C08F 8/04 Reduction, e.g. hydrogenation

Abstract

The present invention is directed to a process for synthesizing hydroxylated plasma-polymerized films, as well as the hydroxylated plasma-polymerized films produced by the process of the invention. In addition, the present invention is directed to the use of hydroxylated plasma-polymerized films produced by the process of the invention for enhancing the compatibility and/or implantability of biomedical implants and/or devices.

Claims

1. A process for producing a hydroxylated plasma-polymerized N-vinyl-2-pyrrolidone polymer comprising the steps of:

a) plasma-polymerizing N-vinyl-2-pyrrolidone monomers to produce an insoluble plasma-polymerized N-vinyl-2-pyrrolidone polymer; and

b) reducing the carbonyl groups in the insoluble plasma-produced N-vinyl-2-pyrrolidone polymer to alcohol groups by chemical reduction using an aqueous solution of sodium borohydride.

2. The hydroxylated plasma-polymerized N-vinyl-2-pyrrolidone polymer produced by the process of claim 1.

3. The process of claim 1, wherein said plasma-polymerization step is radio frequency plasma-polymerization.

4. The process of claim 1, wherein said plasma-polymerized N-vinyl-2-pyrrolidone is a powdered form.

5. A process for producing a hydroxylated plasma-polymerized N-vinyl-2-pyrrolidone film comprising the steps of:

a) plasma-polymerizing N-vinyl-2-pyrrolidone monomers to produce an insoluble plasma-polymerized N-vinyl-2-pyrrolidone film; and

b) immersing the insoluble plasma-polymerized N-vinyl-2-pyrrolidone film in an aqueous solution of sodium borohydride thereby reducing the carbonyl groups in the plasma-polymerized film to hydroxyl groups.

6. The hydroxylated plasma-polymerized N-vinyl-2-pyrrolidone film produced by the process of claim 5.

7. The process of claim 5, wherein aid plasma-polymerization step is by radio frequency plasma polymerization.

8. A process for producing a hydroxylated plasma-polymerized polymer comprising the steps of:

a) utilizing a plasma polymerization process to synthesize an insoluble plasma-polymerized polymer; and

b) adding the synthesized insoluble plasma-polymerized polymer an aqueous solution of a metal hydride thereby reducing the carbonyl groups in the plasma-polymerized polymers to hydroxyl groups.

9. The hydroxylated plasma-polymerized polymer produced by the process of claim 8.

10. The process of claim 8, wherein said metal hydride is sodium borohydride.

11. A process for producing a hydroxylated plasma-polymerized N-vinyl-2pyrrolidone polymer comprising the steps of:

a) plasma-polymerizing N-vinyl-2-pyrrolidone monomers to produce an insoluble plasma-polymerized N-vinyl-2-pyrrolidone polymer rich in carbonyl groups; and

b) reducing the carbonyl groups in the insoluble plasma-produced N-vinyl-2-pyrrolidone polymer to alcohol groups by chemical reduction using an aqueous solution of sodium borohydride.

12. The hydroxylated plasma-polymerized N-vinyl-2-pyrrolidone polymer produced by the process of claim 11.

13. The process of claim 11, wherein said plasma-polymerization step is radio frequency plasma-polymerization.

14. The process of claim 11, wherein said plasma-polymerized N-vinyl-2-pyrrolidone is in powdered form.