Implantable delivery dispenser
First Claim
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1. An improvement in an implantable dispenser for delivering a beneficial agent to an animal, the implantable dispenser comprising:
- (a) a wall in at least a part comprising a composition permeable to the passage of fluid, which wall surrounds;
(b) an internal lumen;
(c) a composition when contacted by fluid increases in volume for displacing a formulation from the implantable dispenser; and
,(d) an exit port in the wall that connects the exterior of the implantable dispenser with the lumen, and wherein the improvement comprises;
(e) a pharmaceutically acceptable beneficial agent formulation in the lumen, which formulation comprises (1) a beneficial agent;
(2) an oil that is a carrier for the agent; and
(3) a polymer that imparts gel properties to the oil, whereby, through the combined operations of (a), (c), (d) and (e) the beneficial agent formulation is delivered at a rate controlled by the implantable dispenser to the animal over time.
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Abstract
An implantable dispenser is enclosed comprising a wall surrounding a compartment containing a first composition comprising a beneficial agent, an oil, a cosolvent and a polymer gellant, a second expandable composition, a third boundary maintaining composition between the first and second composition, and an exit port.
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Citations
19 Claims
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1. An improvement in an implantable dispenser for delivering a beneficial agent to an animal, the implantable dispenser comprising:
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(a) a wall in at least a part comprising a composition permeable to the passage of fluid, which wall surrounds; (b) an internal lumen; (c) a composition when contacted by fluid increases in volume for displacing a formulation from the implantable dispenser; and
,(d) an exit port in the wall that connects the exterior of the implantable dispenser with the lumen, and wherein the improvement comprises; (e) a pharmaceutically acceptable beneficial agent formulation in the lumen, which formulation comprises (1) a beneficial agent;
(2) an oil that is a carrier for the agent; and
(3) a polymer that imparts gel properties to the oil, whereby, through the combined operations of (a), (c), (d) and (e) the beneficial agent formulation is delivered at a rate controlled by the implantable dispenser to the animal over time. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. An implantable dispenser for delivering a beneficial agent to an animal, the implantable dispenser comprising:
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(a) a wall in at least a part comprising a semipermeable composition; (b) an internal lumen; (c) a composition that increases in volume when contacted by fluid in the lumen and thereby aids in pushing a beneficial agent formulation from the implantable dispenser; and
,(d) an exit port in the wall that connects the exterior of the implantable dispenser with the lumen, the implantable dispenser characterized by; (e) a pharmaceutically acceptable formulation in the lumen, the formulation comprising (1) a beneficial agent for delivering to an animal;
(2) a nontoxic oil carrier for the beneficial agent;
(3) a nontoxic cosolvent for increasing the amount of beneficial agent present in the oil carrier; and
(4) a nontoxic polymer gellant for the oil, whereby, through the operations of (a), (c), (d) and (e) the beneficial agent is delivered at a rate controlled by the implantable dispenser to the animal over time. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification