Fast dissolving buccal tablet

• US 5,112,616 A
• Filed: 10/08/1991
• Issued: 05/12/1992
• Est. Priority Date: 11/30/1988
• Status: Expired due to Fees

• Current Assignee: Schering Corporation (Merck & Co., Inc.)
• Original Assignee: Schering Corporation (Merck & Co., Inc.)
• Inventors: McCarty, John A.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Spear, James M.
• Application Number:
  US07/773,183
• Time in Patent Office: 217 Days
• Field of Search: 424/434, 424/435, 424/465
• US Class Current: 424/435
• CPC Class Codes: A61K 9/0056 Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
• CPC Class Codes: A61K 9/2013 Organic compounds, e.g. phospholipids, fats
• CPC Class Codes: A61K 9/2018 Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates

Abstract

A fast dissolving buccal tablet for administering a medicament includes the active ingredient, a lubricant and a water soluble sugar, such as sorbitol, combined such that the buccal tablet dissolves in about one minute.

Claims

1. A buccal tablet comprising:

(a) an effective amount of a buccally absorbable active ingredient;

(b) a buccal tablet excipient selected from the group consisting of;

solids selected from polyethylene glycols and glycerides, which glycerides melt in the range of 25°

to 45°

C.;

surfactants selected from the group consisting of nonionic poly(oxypropylene)poly(oxyethylene) copolymers, polyoxyethylene polysorbate derivatives and sodium lauryl sulfate; and

a combination of a surfactant and a solid, wherein the solid and surfactant are as defined above, said excipient being present in an amount ranging from 90 to 99 percent of the tablet weight; and

(c) a pharmaceutically acceptable lubricant wherein the lubricant is magnesium stearate or sodium dodecyl sulfate in an amount ranging from 1 to 3 percent of the tablet weight;

wherein the lubricant is chosen so that disintegration occurs from 0.5 to 5 minutes after administration.