Method and a device for preparing a mixture of a solid and a liquid component

• US 5,114,240 A
• Filed: 05/10/1990
• Issued: 05/19/1992
• Est. Priority Date: 05/12/1989
• Status: Expired due to Fees

• Current Assignee: Wolff & Kaaber A/S Rugmarken 28 Dk-3520 Farum
• Original Assignee: Wolff & Kaaber A/S
• Inventors: Morris, Michael, Kindt-Larsen, Ture, Wolff, Per
• Primary Examiner(s): Coe, Philip R.
• Assistant Examiner(s): Alexander, Reginald L.
• Application Number:
  US07/521,733
• Time in Patent Office: 740 Days
• Field of Search: 366/129, 366/130, 366/332, 366/333, 366/348, 366/349, 366/341, 366/240, 366/289, 366/309, 206/219, 222/541, 222/136, 222/190, 604/224
• US Class Current: 366/129
• CPC Class Codes: A61B 17/8816 characterised by the conduit, e.g. tube, along which fluid flows into the body or by conduit connections
• CPC Class Codes: A61B 17/8825 characterised by syringe details A61B17/8822, A61B17/8827 take precedence
• CPC Class Codes: A61B 17/8827 with filtering, degassing, venting or pressure relief means
• CPC Class Codes: A61B 2017/8838 for mixing bone cement or fluid fillers
• CPC Class Codes: A61B 2050/0066 with additional sealing means, e.g. O-ring
• CPC Class Codes: A61B 2090/037 with a frangible part, e.g. by reduced diameter
• CPC Class Codes: A61C 5/64 for multi-component compositions
• CPC Class Codes: A61C 5/66 Capsules for filling material
• CPC Class Codes: A61F 2250/0071 breakable or frangible
• CPC Class Codes: B01F 2101/20 Mixing of ingredients for bone cement
• CPC Class Codes: B01F 23/565 by introducing liquids in solid material, e.g. to obtain slurries
• CPC Class Codes: B01F 33/5011 portable during use, e.g. hand-held
• CPC Class Codes: B01F 35/713 comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartments or cartridges containers or packages per se B65D
• CPC Class Codes: B01F 35/7137 Piercing, perforating or melting membranes or closures which seal the compartments
• CPC Class Codes: B01F 35/7162 A container being placed inside the other before contacting the contents
• CPC Class Codes: B01F 35/75 Discharge mechanisms
• CPC Class Codes: B01F 35/754251 reciprocating in the mixing receptacle

Abstract

A mixing device comprises a first cylinder (10) containing a particulate or powdered component (11) and having a closed first end (13, 14) and an opposite second end which is closed by a piston-like venting and filtering assembly (12, 15). The device also comprises a second cylinder (18) containing the liquid component (19) and having a closed end (20, 22) and an opposite open end sealingly receiving the closed end of the first cylinder (10) therein in a piston-like manner. Means (14) are provided for communicating between the inner space of the first and second cylinders (10, 18) through the closed end (13, 14) of the first cylinder (10), when the first cylinder is forced into the second cylinder, whereby liquid from the first cylinder is injected into interstices defined between the particulate component contained in the first cylinder for providing a paste-like material. The communicating means is preferably formed by a breakable membrane (14). The venting and filtering assembly (12, 15) may be used as a piston for discharging the paste-like mixture made from the first cylinder (10). The mixing device is preferably used for mixing components so as to form a bone cement.

Claims

1. A method of preparing a mixture of a solid, particulate or powdered first component and a liquid second component so as to provide a paste-like material, said method comprising:

arranging the first component in a first cylinder, the size of particles of said first component being such that coherent liquid-receiving interstices are defined therebetween;

arranging the liquid second component in a second cylinder having a closed first end and an opposite second end, a first end of the first cylinder being arranged in the second end of the second cylinder in a piston-like manner and in sealing relation thereto;

forcing said liquid second component into the first cylinder by relatively moving the first cylinder towards the closed end of the second cylinder while venting the first cylinder at a second end of the first cylinder opposite to said first end thereof, whereby the liquid second component is received in said interstices in said first component thereby mixing said first and second components together, said step of mixing including venting any gaseous material in said first cylinder to the atmosphere during said relative movement thereby to achieve a substantially homogeneous mixture comprising said paste-like material; and

subsequently expelling said mixture of said first component and said liquid second component mixed to form said paste-like material from the first cylinder, said step of expelling comprising forcing said paste-like material toward said closed end of said second cylinder, said closed end of said second cylinder having a discharge orifice disposed therein, through which said paste-like material is discharged.

2. A method according to claim 1, wherein the mixture is compacted prior to expelling.

3. A method according to claim 1, wherein the mixture is allowed to mature for a predetermined period of time prior to expelling.

4. A method according to claim 1, wherein the step of venting the first cylinder comprises venting through a gas-permeable wall part or filter impermeable to the particles of the first component.

5. A method according to claim 1, wherein the size of the main part of the particles of the first component arranged in the first cylinder is between 15 and 300μ

.

6. A method according to claim 1, wherein the size of the particles of the first component arranged in the first cylinder is between 25 and 250μ

.

7. A method according to claim 1, wherein the size of the particles of the first component arranged in the first cylinder is between 50 and 200μ

.

8. A method according to claim 1, wherein a rupturable wall is disposed in the first end of the first cylinder, and said step of forcing the liquid second component into the first cylinder comprises rupturing said wall by the step of relatively moving said first cylinder towards the closed end of the second cylinder and further wherein said step of expelling comprises moving a piston member disposed in the first cylinder toward the closed end of the second cylinder.

9. A method according to claim 1, wherein the paste-like material is an acrylate bone cement composition.

10. A method according to claim 1, wherein the step of expelling further comprises breaking a rupturable seal disposed at said discharge orifice thereby allowing the discharge of said paste-like material through said discharge orifice.

11. A method according to claim 10, wherein the step of breaking the rupturable seal comprises moving said piston member in said first cylinder, thereby rupturing said rupturable seal.

12. A mixing device for mixing a solid, particulate or powdered first component and a liquid second component so as to provide a paste-like material therefrom, said device comprising:

a first cylinder for containing said first component and having a first end and an opposite second end provided with venting means;

a second cylinder for containing said liquid second component and having a first end and an opposite second end sealingly receiving the first end of the first cylinder in a piston-like manner;

means for providing communication between inner spaces of the first and second cylinders through at least one of said first end of the first cylinder and said second end of said second cylinder, thereby allowing the liquid second component from the second cylinder to be injected into interstices defined between particles of the first component contained in the first cylinder for providing said paste-like material, when said first cylinder is relatively moved into the second cylinder;

said venting means comprising means for allowing gaseous matter to be removed to the atmosphere from said first cylinder during relative movement of said first and second cylinders thereby allowing said first and second components to mix to form a substantially homogeneous mixture comprising said paste-like material in said first cylinder; and

further comprising;

a discharge orifice at the closed first end of the second cylinder for providing said paste-like material from said first cylinder; and

means for expelling said mixed paste-like material out of the first cylinder through the orifice.

13. A device according to claim 12, wherein the expelling means comprises a piston member displaceably arranged in said second end of the first cylinder.

14. A device according to claim 13, wherein said piston member comprises releasable locking means for retaining the piston member immobile in relation to the first cylinder, the locking means being released when the piston member is exposed to a second inwardly directed axial pressure substantially exceeding said predetermined first differential pressure.

15. A device according to claim 14, wherein said locking means comprise one or more projections extending radially from the piston member and engaging with the first cylinder or a member connected thereto.

16. A device according to claim 15, wherein said radial projections comprise a flexible annular collar member or bead.

17. A device according to claim 14, wherein a wall part of the closed first end of the second cylinder comprises rupturable means which is breakable when exposed to a predetermined third differential pressure.

18. A device according to claim 17, further comprising a removable back-up member arranged in supporting engagement with the outer surface of said breakable wall part of the closed first end of the second cylinder for preventing premature rupturing of said breakable wall part.

19. A device according to claim 12, wherein the means for providing communication comprises a wall part of the first end of the first cylinder which is breakable when exposed to a predetermined first differential pressure.

20. A device according to claim 19, wherein said breakable wall part is a breakable membrane.

21. A device according to claim 19, wherein a wall part of the closed first end of the second cylinder comprises rupturable means which is breakable when said means for expelling forces said paste-like material against said rupturable means.

22. A device according to claim 13, wherein the venting means is arranged in said piston member.

23. A device according to claim 22, wherein said venting means comprises vapor-absorbing filtering means.

24. A device according to claim 23, wherein said filtering means comprises activated carbon.

25. A device according to claim 12, wherein said expelling means comprises a piston-like filter device which is displaceably arranged within the first cylinder for defining a first component material-receiving space between the filter device and said closed first end of the first cylinder.

26. A device according to claim 25, wherein the filter device comprises filtering means which is penetrable to gas, but impervious to liquid.

27. A device according to claim 26, wherein the filtering means comprises a filtering medium which swells when contacted by the liquid component.

28. A device according to claim 12, wherein the first component and the liquid second component are components forming bone cement when mixed.

29. A device according to claim 28, wherein the first component contained in the first cylinder comprises a polymer component having particles of a size between 15 and 300μ

.

30. A device according to claim 29, wherein the size of the particles of the polymer component contained in the first cylinder is between 25 and 250μ

.

31. A device according to claim 30, wherein the size of the particles of the polymer component contained in the first cylinder is between 50 and 200μ

.

32. A device according to claim 12, wherein the first cylinder contains a polymer component comprising (meth)acrylate polymers or copolymers or a mixture thereof and wherein the second cylinder contains a liquid monomeric (meth)acrylate.

33. A device according to claim 32, wherein the polymer component further comprises X-ray contrast particles.

34. A device according to claim 12, wherein the means for providing communication comprises a wall part of the first end of the first cylinder which is breakable during relative movement of the first and second cylinders.

35. A device according to claim 12, wherein a wall part of the closed first end of the second cylinder comprises rupturable means which is breakable when said means for expelling forces said paste-like material against said rupturable means.

36. A device according to claim 35, further comprising a removable back-up member arranged in supporting engagement with the outer surface of said breakable wall part of the closed first end of the second cylinder for preventing premature rupturing of said breakable wall part.