Hyperosmolar oxyreplete hemosubstitute

• US 5,114,932 A
• Filed: 11/30/1990
• Issued: 05/19/1992
• Est. Priority Date: 11/30/1990
• Status: Expired due to Term

• Current Assignee: Thomas M. Runge
• Original Assignee: Thomas M. Runge
• Inventors: Runge, Thomas M.
• Primary Examiner(s): GRIFFIN, RONALD
• Application Number:
  US07/620,539
• Time in Patent Office: 536 Days
• Field of Search: 514/6, 514/832, 514/833, 514/23, 514/60, 514/769, 514/777, 514/58, 530/385
• US Class Current: 514/58
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/025 carbocyclic
• CPC Class Codes: A61K 31/13 Amines A61K31/04 takes precedence
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/33 Heterocyclic compounds
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 33/04 Sulfur, selenium or tellurium; Compounds thereof
• CPC Class Codes: A61K 33/10 Carbonates; Bicarbonates
• CPC Class Codes: A61K 33/14 Alkali metal chlorides; Alkaline earth metal chlorides
• CPC Class Codes: A61K 33/42 Phosphorus; Compounds thereof
• CPC Class Codes: A61K 38/42 Haemoglobins; Myoglobins
• CPC Class Codes: A61K 9/0026 Blood substitute; Oxygen transporting formulations; Plasma extender

Abstract

New blood substitutes are described having osmolarities greater than normal blood. The new blood substitues typically comprise a physiologically acceptable fluid electrolyte solution, a physiologically acceptable agent capable of increasing the osmolarity of the blood substitute to a value greater than normal blood, an oxygen carrying substance, and a sufficient amount of water to achieve the desired osmolarity. The blood substitutes of the present invention have osmolarities in the range of 500-800 milliosmoles per liter.

Claims

1. A blood substitute comprising an oxygen carrier and having an osmolarity greater than 303 milliosmoles per liter.

2. The blood substitute of claim 1 having an osmolarity in the range of 500-800 milliosmoles per liter.

3. The blood substitute of claim 2 having an osmolarity in the range of 600-800 milliosmoles per liter.

4. The blood substitute of claim 1 comprising a perfluorocarbon emulsion and a disaccharide.

5. A hyperosmolar blood substitute comprising an oxygen carrier and a physiologically acceptable molecule having a molecular trait less diffusible than dextrose and wherein said substitute has an osmolarity greater than 303 milliosmoles per liter.

6. The blood substitute of claim 5, wherein the oxygen carrying agent is a perfluorocarbon.

7. The blood substitute of claim 5, wherein said molecule less diffusible than dextrose is a disaccharide.

8. The blood substitute of claim 7, wherein the disaccharide is sucrose.

9. The blood substitute of claim 5, wherein the oxygen carrying substance is a synthetic hemoglobin or recombinant hemoglobin.

10. A blood substitute comprising an oxygen carrier and a cyclodextrin and wherein said substitute has an osmolarity greater than 303 milliosmoles per liter.

11. A hyperosmolar blood substitute composition comprising:

(a) a physiologically acceptable fluid electrolyte solution;

(b) a physiologically acceptable agent capable of increasing the osmolarity of said blood substitute to a value greater than that of protein free blood;

(c) an oxygen carrying substance; and

(d) a sufficient amount of water to achieve the desired osmolarity.

12. A hyperosmolar priming solution comprising:

(a) physiologically acceptable electrolytes and

(b) a physiologically acceptable agent capable of increasing the osmolarity of said priming solution to a value in the range of 500 to 800 milliosmoles per liter.

13. A blood substitute comprising:

(a) a hyperosmolar priming solution; and

(b) an oxygen carrying synthetic substance.

14. A blood substitute having an osmolarity greater than normal human blood comprising in addition to those physiologically acceptable crystalloids present in normal blood, a physiologically acceptable oxygen carrier substance selected from the group consisting of a perfluorocarbon, a synthetic hemoglobin, a recombinant hemoglobin and mixtures thereof and a physiologically acceptable disaccharide.