Method and system for treatment of AIDS

• US 5,116,307 A
• Filed: 07/09/1990
• Issued: 05/26/1992
• Est. Priority Date: 07/09/1990
• Status: Expired due to Term

• Current Assignee: Harvey T. Collins
• Original Assignee: Harvey T. Collins
• Inventors: Collins, Harvey T.
• Primary Examiner(s): Hafer, Robert A.
• Assistant Examiner(s): NOT, DEFINED
• Application Number:
  US07/549,961
• Time in Patent Office: 687 Days
• Field of Search: 604/4-6, 604/317-320, 210/764
• US Class Current: 604/6.13
• CPC Class Codes: A61M 1/30 Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/304 Treatment chamber used as reservoir, e.g. centrifuge bowl or filter with movable membrane
• CPC Class Codes: A61M 1/32 Oxygenators without membranes
• CPC Class Codes: A61M 1/3687 Chemical treatment A61M1/3675 takes precedence
• CPC Class Codes: A61M 5/1483 using flexible bags externally pressurised by fluid pressure

Abstract

The method and system for the extracorporeal or extravascular treatment of blood employs diethyl ether for killing HIV cells in the blood. In practicing the method with the system, blood is withdrawn from one arm of a patient through a tubing to a container, e.g. a syringe barrel, where the blood is exposed to vaporized diethyl ether, which has been vaporized by heating, thereby to enable the diethyl ether to strip the viral envelope away from HIV cells attached to macrophages and dissolve the lipid layers thereof thereby to kill the HIV cells. The blood with ether is then passed through a manifold where a vacuum is drawn on the blood to remove most of the ether from the blood. The treated blood is then returned by a tubing and needle to the other arm of the patient. A blood thinner or anticoagulant preferably is given first to the patient orally or intravenously. Also preferably an electrical pulse is supplied to the arm of the patient upstream of the point where blood is removed for the purpose of inhibiting the clumping of the infected white blood cells to non-infected white blood cells thereby to force the HIV cells, or macrophages containing HIV cells, into the blood stream so that they are more vulnerable to being destroyed by the ether. Further, if desired, new blood can be introduced into the patient'"'"'s other arm with the returned treated blood to provide "make up" blood cells for blood cells that may have been destroyed by the ether.

Claims

1. A method for the extracorporeal or extravascular treatment of blood for killing virus cells in the blood comprising the steps of:

withdrawing blood from one arm of a patient;

passing the withdrawn blood through a container;

exposing the blood in the container to vaporized diethyl ether, which has been vaporized by heating, thereby to enable the diethyl ether to strip the viral envelope away from the virus cells and dissolve the lipid layers of same in the blood thereby to kill the virus cells;

passing the blood through a manifold;

drawing a vacuum on the blood in the manifold to remove most of the ether from the blood; and

returning the treated blood to the other arm of the patient.

2. The method of claim 1 including the first step of supplying a blood thinner or anticoagulant to the patient.

3. The method of claim 1 including the step of supplying an electrical pulse to the arm of the patient upstream of the point where blood is removed for the purpose of inhibiting the clumping of infected white blood cells to non-infected white blood cells thereby to force HIV cells, or macrophages containing HIV cells, into the blood stream so that they are more vulnerable to being destroyed by the ether.

4. The method of claim 1 including the step of supplying new blood to the patient'"'"'s arm with the returned treated blood to provide the patient with "make up" blood cells for blood cells that may have been destroyed by the ether.

5. A system for the extracorporeal or extravascular treatment of blood for killing virus cells in the blood comprising:

means for withdrawing blood from one arm of a patient;

a container;

means for passing the withdrawn blood through said container;

means for exposing the blood in said container to vaporized diethyl ether, which as been vaporized by heating, thereby to enable the diethyl ether to strip the viral envelope away from the virus cells and dissolve the lipid layers of same in the blood thereby to kill the virus cells;

a manifold;

means for passing the blood through said manifold;

means for drawing a vacuum on the blood in said manifold to remove most of the ether from the blood; and

means for returning the treated blood to the other arm of the patient.

6. The apparatus of claim 5 including means for supplying an electrical pulse to the arm of the patient upstream of the point where blood is removed for the purpose of inhibiting the clumping of infected white blood cells to noninfected white blood cells thereby to force HIV cells, or macrophages containing HIV cells, into the blood stream so that they are more vulnerable to being destroyed by the ether.