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Material for affinity chromatography which is a sulfated polysaccharide bonded to an insoluble polymer

  • US 5,116,962 A
  • Filed: 07/16/1990
  • Issued: 05/26/1992
  • Est. Priority Date: 05/25/1985
  • Status: Expired due to Term
First Claim
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1. A sulfated polysaccharide bonded to an insoluble polymer prepared by a process which comprises treating a sulfated polysaccharide selected from the group consisting of heparin and its sodium salt with an alkali metal periodate which oxidizes glycols to aldehydes, thereby cleaving the carbon chain, and reacting the modified sulfated polysaccharide with an insoluble polymer containing amino groups selected from the group consisting of dextran resins, agarose resins and copolymers of methacrylic acid derivatives, pentaerythritol, polyethylene glycol and divinylbenzene.

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