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Analytical element for analysis of whole blood

  • US 5,118,472 A
  • Filed: 07/08/1988
  • Issued: 06/02/1992
  • Est. Priority Date: 07/08/1987
  • Status: Expired due to Term
First Claim
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1. In an integral multilayer analytical element which comprises a first nonfibrous porous layer, a second nonfibrous porous layer, and a fibrous porous layer superposed in this order to a water-impermeable light-transmissive support, the above three porous layers being integrally laminated to each other by an adhesive layer discontinuously disposed so as to form microspaces continuing through from one layer to the next so as not to interfere with the approximately uniform permeation of a liquid, a reagent composition to produce an optically detectable change in the presence of an analyte being incorporated into at least one of said three porous layers, the improvement which comprises the void volume per unit area of the first nonfibrous layer being less than half of the void volume per the unit area of the second nonfibrous porous layer and wherein the effective pore size of the first non-fibrous layer is not larger than three times that of the second non-fibrous layer.

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