Endovascular electrolytically detachable guidewire tip for the electroformation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas

• US 5,122,136 A
• Filed: 03/13/1990
• Issued: 06/16/1992
• Est. Priority Date: 03/13/1990
• Status: Expired due to Term

• Current Assignee: Blossom Flower Inc, Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Guglielmi, Guido, Sepetka, Ivan
• Primary Examiner(s): Cohen, Lee S.
• Application Number:
  US07/492,717
• Time in Patent Office: 826 Days
• Field of Search: 606/32, 606/41, 606/49, 606/28, 128/772, 128/784, 128/786
• US Class Current: 606/32
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/1214 Coils or wires
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/1215 comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2017/00292 mounted on or guided by flexible, e.g. catheter-like, means
• CPC Class Codes: A61B 2017/12063 electrolytically detachable
• CPC Class Codes: A61B 2017/22038 with a guide wire
• CPC Class Codes: A61B 2018/00678 upper
• CPC Class Codes: A61B 2018/00761 Duration
• CPC Class Codes: A61B 2018/00875 Resistance or impedance
• CPC Class Codes: A61B 2018/00886 Duration
• CPC Class Codes: A61B 2018/1226 powered by a battery
• CPC Class Codes: A61B 2018/1253 monopolar
• CPC Class Codes: A61B 2018/126 bipolar
• CPC Class Codes: A61B 2018/1266 with DC current output
• CPC Class Codes: A61B 2018/1435 Spiral
• CPC Class Codes: A61B 2018/1495 Electrodes being detachable from a support structure
• CPC Class Codes: A61B 2090/3966 Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61B 90/39 : Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61M 2025/0042 : Microcatheters, cannula or the like having outside diameters around 1 mm or less
• CPC Class Codes: A61M 2025/09175 : having specific characteristics at the distal tip
• CPC Class Codes: A61M 25/09 : Guide wires

Abstract

An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular electrothrombosis by the endovascular insertion of a platinum guidewire tip into the vascular cavity followed by application of a positive current. The guidewire tip is then separated from the guidewire by electrolytic separation of the tip from the guidewire. A portion of the guidewire connected between the tip and the body of the guidewire is comprised of stainless steel and exposed to the bloodstream so that upon continued application of a positive current to the exposed portion, the exposed portion is corroded away at least at one location and the tip is separated from the body of the guidewire. The guidewire and the microcatheter are thereafter removed leaving the guidewire tip embedded in the thrombus formed within the vascular cavity.

Claims

1. A method for forming an occlusion within a vascular cavity having blood disposed therein comprising the steps of:

endovascularly disposing a guidewire near an endovascular opening into said vascular cavity;

disposing a distal tip of said guidewire into said vascular cavity to form said occlusion within said vascular cavity about said distal tip; and

detaching said distal tip from said guidewire to leave said distal tip within said vascular cavity and said occlusion being formed within said vascular cavity,

whereby said vascular cavity is occluded by said distal tip, and any thrombus formed by use of said tip.

2. The method of claim 1 where said step of disposing said distal tip in said vascular cavity further comprises the step of substantially occupying said vascular cavity with said distal tip.

3. The method of claim 2 where said step of substantially occupying said vascular cavity comprises the step of filling said vascular cavity with a long and pliable length of said distal tip.

4. The method of claim 1 wherein said step of detaching said distal tip from said guidewire comprises the step of electrolytically detaching said distal tip from said guidewire.

5. The method of claim 4 where said step of electrolytically detaching said distal tip from said guidewire comprises the step of electrolytically disintegrating at least one portion of a connecting segment extending between said guidewire and said distal tip.

6. The method of claim 5 where said step of electrolytically disintegrating said connecting segment comprises the step of electrolytically corroding away at least a portion of a coil segment.

7. The method of claim 6 where said step of electrolytically corroding said coil segment comprises the step of electrolytically disintegrating a stainless steel coil segment.

8. The method of claim 1 wherein said step of disposing said distal tip comprises the step of applying an electrical signal to said distal tip to form said thrombus by applying a positive direct current for a first predetermined time period.

9. The method of claim 8 wherein said step of detaching said distal tip from said guidewire comprises the step of applying a positive direct current to said distal tip for an additional predetermined time period separate from said first predetermined time period.

10. The method of claim 8 where in said step of detaching said distal tip from said guidewire, the location of detachment of said tip from said guidewire is unexposed during said first predetermined time period, and is exposed to blood during an additional predetermined time period.

11. The method of claim 1 wherein said step of detaching said distal tip from said guidewire comprises the step of applying a positive direct current to said distral tip for a predetermined time period.

12. The method of claim 1 wherein said step of disposing said tip comprises the step of disposing said guidewire in a first position relative to said vascular cavity so that a disintegratable portion of said tip remains insulated from said blood during application of a first electrical signal to said tip, and where said step of detaching comprises moving said disintegratable portion of said tip to a second position where said disintegratable portion is exposed to said blood, applying a second electrical signal to said disintegratable portion to electrolytically dissolve said disintegratable portion in said blood.

13. A guidewire for use in formation of an occlusion within a vascular cavity used in combination with a microcatheter comprising:

a core wire, said core wire having a distal portion susceptible to electrolytic distintegration in blood; and

an elongate tip portion extending said core wire for a predetermined lineal extent adapted to form said occlusion in said vascular cavity and coupled to said distal portion of said core wire tip portion for endovascular insertion within a vascular cavity, said elongate tip portion not being susceptible to electrolytic disintegration in blood,

whereby endovascular occlusion of said vascular cavity can be performed.

14. The guidewire of claim 13 wherein said distal portion of said core wire is an exposed stainless steel segment.

15. The guidewire of claim 14 wherein said stainless steel segment comprises a coil having a proximate and distal end, and connected at its proximate end to said core wire and connected at its distal end to said elongate tip portion of said guidewire.

16. The guidewire of claim 15 wherein said core wire is extended in a threadlike portion concentrically within said stainless steel coil from a proximal end of said stainless steel coil to where said stainless steel coil is connected to said elongate tip portion of said guidewire.

17. The guideware of claim 15 wherein said coil defines an interior space, said interior space being free and unreinforced.

18. The guideware of claim 13 wherein said elongate tip portion is a long and substantially pliable segment and is comprised of a metal not susceptible to electrolytic disintegration within blood.

19. the guidewire of claim 18 wherein said long and pliable segment of said elongate tip portion has a length sufficient to substantially fill said vascular cavity when inserted therein.

20. The guidewire of claim 13 wherein said elongate tip portion is comprised of 479 platinum alloy.

21. A guidewire for use in formation of an occlusion used in combination with a microcatheter comprising:

a core wire, said core wire having a distal portion susceptible to electrolytic disintegration in blood; and

an elongate tip portion extending said core wire for a predetermined lineal extent and coupled to said distal portion of said core wire, said tip portion for endovascular insertion within a vascular cavity, said elongate tip portion not being susceptible to electrolytic disintegration in blood,

wherein said elongate tip portion is a long and substantially pliable segment and is comprised of a mental not susceptible to electrolytic disintegration within blood, and

wherein said long and pliable segment is prebiased to form a helix when extended from said microcatheter,

whereby endovascular occlusion of said vascular cavity can be performed.

22. the guidewire of claim 21 wherein said helix has a conical envelope.

23. The guidewire of claim 21 wherein said helix has a cylindrical envelope.