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Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same

  • US 5,123,414 A
  • Filed: 08/26/1991
  • Issued: 06/23/1992
  • Est. Priority Date: 12/22/1989
  • Status: Expired due to Term
First Claim
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1. A method of synthesizing a liposome having encapsulated therein a gas and employing said liposome in medical imaging, comprising the steps of:

  • (a) placing a liquid media containing liposomes in a vessel,(b) pressurizing said vessel with a cooled gas, thereby dissolving a first portion of said gas into said liquid media, so that a portion of said dissolved gas enters said liposomes,(c) rapidly depressurizing said vessel by releasing a second portion of said gas from said vessel, thereby causing said dissolved gas having entered said liposomes to form bubbles within said liposomes,(d) administering said liposomes to a patient, and(e) scanning said patient with a medical imaging device to obtain enhanced visible images of an internal region of said patient.

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