Polyesters for use in blood partitioning compositions
First Claim
1. A polyester comprising about one mole of a dicarboxylic acid member and one mole of a diol member wherein said acid member is comprised of a first dicarboxylic acid component having from about 5 to about 60 mole percent of an aliphatic dicarboxylic acid having from 13 to about 22 carbon atoms, a second dicarboxylic acid component having from about 35 to about 90 mole percent of an aliphatic dicarboxylic acid having from 4 to about 12 carbon atoms, a third dicarboxylic acid component having from about 5 to about 25 mole percent of an aliphatic dicarboxylic acid having about 36 carbon atoms, said polyester being in the form of a viscous liquid and having a density at room temperature in the range of 1.01-1.09.
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Accused Products
Abstract
A polyester is provided which facilitates the separation of blood into light and heavy phases via centrifugation in a blood collection vessel. The polyester is useful as a component of a partitioning composition formulated to have appropriate specific gravity to be positioned intermediate the light and heavy blood phases during centrifugation. A partitioning composition including a polyester of the invention provides a particular advantage in blood collection vessels used in therapeutic drug monitoring, due to the relatively low affinity between the polyester component of the composition and commonly monitored classes of drugs.
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Citations
10 Claims
- 1. A polyester comprising about one mole of a dicarboxylic acid member and one mole of a diol member wherein said acid member is comprised of a first dicarboxylic acid component having from about 5 to about 60 mole percent of an aliphatic dicarboxylic acid having from 13 to about 22 carbon atoms, a second dicarboxylic acid component having from about 35 to about 90 mole percent of an aliphatic dicarboxylic acid having from 4 to about 12 carbon atoms, a third dicarboxylic acid component having from about 5 to about 25 mole percent of an aliphatic dicarboxylic acid having about 36 carbon atoms, said polyester being in the form of a viscous liquid and having a density at room temperature in the range of 1.01-1.09.
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8. A polyester which comprises as the acid member:
- (i) about 10 mole percent of linoleic acid-acrylic acid adduct having 21 carbon atoms as the first acid component, (ii) about 75 mole percent of a mixture of dimethyl succinate, dimethyl glutarate, and dimethyl adipate as the second acid component, and (iii) about 15 mole percent of oleic dimer acid as the third acid component and a diol member comprising neopentyl glycol and propylene glycol wherein the molar ratio of said acid member to said diol member is about 1;
1. - View Dependent Claims (9, 10)
- (i) about 10 mole percent of linoleic acid-acrylic acid adduct having 21 carbon atoms as the first acid component, (ii) about 75 mole percent of a mixture of dimethyl succinate, dimethyl glutarate, and dimethyl adipate as the second acid component, and (iii) about 15 mole percent of oleic dimer acid as the third acid component and a diol member comprising neopentyl glycol and propylene glycol wherein the molar ratio of said acid member to said diol member is about 1;
Specification