Method and apparatus for controlled environment electrotransport

• US 5,125,894 A
• Filed: 03/30/1990
• Issued: 06/30/1992
• Est. Priority Date: 03/30/1990
• Status: Expired due to Fees

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Phipps, Joseph B., Moodie, Lyn C.
• Primary Examiner(s): Jaworski, Francis
• Assistant Examiner(s): AKERS, SCOTT
• Application Number:
  US07/502,232
• Time in Patent Office: 823 Days
• Field of Search: 128/783, 128/798, 128/799, 128/803, 604/20
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0436 Material of the electrode
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0444 Membrane
• CPC Class Codes: A61N 1/0448 Drug reservoir

Abstract

Methods for conducting controlled environment electrotransport are described. The methods generally concern control of the ionic environment of the active electrode reservoir, in an electrotransport system. This control may be utilized, for example, to maintain a constant extraneous ion presence, such as pH. It may also be applied in a preferred manner to maintain selected control over the delivery rate of a target species, in time, in the presence of extraneous ions. Apparatus usable to provide for controlled environment electrotransport are also described. In general the apparatus comprises an electrotransport system including an active electrode reservoir having therein both a primary electrode arrangement and a secondary electrode arrangement, with a control arrangement for selected operation of both. The secondary electrode arrangement, being operated different from the primary electrode arrangement, is selected for operation to selectively enhance or otherwise modify ion presence in the active electrode reservoir, to achieve application of the general methods described. The apparatus may include a sensor means therein, for use as feedback to a control system during operation. Methods and systems involving diffusion type delivery are also described.

Claims

1. A method of conducting electrotransport comprising the steps of:

(a) selectively operating a primary electrode arrangement to provide electromotive force to transport ions from an active electrode reservoir; and

,

(b) selectively operating a secondary electrode arrangement such that the effect of the electrochemical reactions generated by the secondary electrode arrangement on the ionic content of the active electrode reservoir is different from that of the primary electrode arrangement, to selectively effect relative concentrations of ions in the active electrode reservoir.

2. A method according to claim 1 wherein:

(a) said step of operating a primary electrode arrangement comprises operating the primary electrode arrangement as an anode; and

,

(b) said step of selectively operating a secondary electrode arrangement comprises selectively operating the secondary electrode arrangement as an anode.

3. A method according to claim 2 wherein:

(a) said step of operating a primary electrode arrangement includes operation to transport at least one target cation species and at least one extraneous cation species from the active electrode reservoir; and

,

(b) said step of selectively operating a secondary electrode arrangement includes introducing at least one extraneous cation species into the active electrode reservoir.

4. A method according to claim 1 wherein:

(a) said step of operating a secondary electrode arrangement is conducted to selectively maintain a concentration of a selected ion species in the active electrode reservoir at a constant level.

5. A method according to claim 4 wherein:

(a) said step of operating a secondary electrode arrangement is conducted to selectively maintain pH in the active electrode reservoir substantially constant during said step of operating a primary electrode arrangement.

6. A method according to claim 1 wherein:

(a) said step of operating a primary electrode arrangement includes operation to transport at least one target ion species and at least one extraneous ion species from the active electrode reservoir; and

,

(b) said step of selectively operating a secondary electrode arrangement includes introducing at least one extraneous ion into the active electrode reservoir;

the extraneous ions introduced into the active electrode reservoir by the secondary electrode arrangement including at least one of the same species as transported therefrom by the primary electrode arrangement.

7. A method according to claim 1 wherein:

(a) said step of continuously operating a primary electrode arrangement includes operation to transport at least one target ion species and at least one extraneous ion species from the active electrode reservoir; and

,

(b) said step of selectively operating a secondary electrode arrangement includes operation to remove at least one extraneous ion from the electrode reservoir by means other than transport.

8. A method according to claim 1 including a steps of:

(a) modifying relative current flow through the primary electrode arrangement and the secondary electrode arrangement during said method; and

,

(b) selectively adjusting relative current flow through the primary electrode arrangement and the secondary electrode arrangement to maintain a constant current flow through a subject of the electrotransport.

9. A method according to claim 1 including the steps of:

(a) providing a selected initial extraneous ion concentration in the active electrode reservoir at initiation of said step of operating the primary electrode arrangement; and

,

(b) conducting the operation of the secondary electrode arrangement in a manner constantly maintaining a concentration of extraneous ions within 30% of the initial extraneous ions concentration, throughout said step of operating the primary electrode arrangement.

10. A method according to claim 1 including a step of operating both of the primary electrode arrangement and the secondary electrode arrangement, by passage of current therethrough, simultaneously during at least a portion of said electrotransport.