Bar coding calibration
First Claim
1. A method of providing data in bar code form useful for the determination of the calibration curve of a lot of test elements in a clinical analyzer using a finite numbering system limited to n-digit decimal numbers, said curve having the mathematical formula
where C is the predicted concentration of a sample liquid analyzed by the analyzer, R is the response actually measured in the analyzer or a cubic spline function of that response, K is a coefficient assigned to the analyzer, and a0, a1 and a2 are said calibration coefficients which can vary beyond that which can be specified using (10n) digits;
R+a.sub.2 ·
(R).sup.K (
1)
the method comprising the steps of;
a) ascertaining by statistical analysis the ranges of values for R that are possible for three given concentration values C1, C2 and C3, for a given assay, and assigning a high value H and a low value L for these ranges;
b) calculating for a given lot of the given assay, a calibration curve that correlates the analyzer response to the concentration;
c) determining the analyzer response R1, R2 and R3 from said calibration curve, that corresponds to said C1, C2 and C3 values;
d) calculating the bar code value Bi for Ri of each of these R1, R2 and R3 from the equation
space="preserve" listing-type="equation">B.sub.i =(10.sup.n -1)(R.sub.i -L.sub.i)/(H.sub.i -L.sub.i)(2) where Ri is R1, R2 or R3, and Li and Hi are the corresponding L and H values for that Ri ;
e) rounding Bi to the nearest integer; and
f) supplying this value of Bi for each of Ri =R1, R2 or R3 in bar code form,so that only three sets of (10n) possibilities are needed to accurately pass along data corresponding to said calibration coefficients even though each of said three coefficients can vary by more than that which can be specified using 10n digits.
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Accused Products
Abstract
There is described a method of barcoding data needed to determine a calibration curve for a test element in an analyzer. The process follows the steps of:
a) ascertaining by statistical analysis the ranges of values for R that are possible for three given concentration values C1, C2 and C3, for a given assay, and assigning a high value H and a low value L for these ranges;
b) calculating for a given lot of the given assay, a calibration curve that correlates the analyzer response to the concentration,
c) determining the analyzer response R1, R2 and R3 from said calibration curve, that corresponds to the C1, C2 and C3 values;
d) calculating the bar code value Bi for Ri of each of these R1, R2 and R3 from the equation:
B.sub.i =(10.sup.n -1)(R.sub.i -L.sub.i)/(H.sub.i -L.sub.i) (2)
where Ri is R1, R2 or R3, and Li and Hi are the corresponding L and H values for that Ri ;
e) rounding Bi to the nearest integer; and
f) supplying this value of Bi for each of Ri =R1, R2 or R3 in bar code form, using n-digit decimal numbers,
so that only three sets of (10n) possibilities are needed to accurately pass along data corresponding to the calibration coefficients even though each of the three coefficients can vary by more than that which can be specified using 10n digits.
60 Citations
3 Claims
- 1. A method of providing data in bar code form useful for the determination of the calibration curve of a lot of test elements in a clinical analyzer using a finite numbering system limited to n-digit decimal numbers, said curve having the mathematical formula
- space="preserve" listing-type="equation">C=a.sub.0 +a.sub.1 ·
R+a.sub.2 ·
(R).sup.K (
1)
where C is the predicted concentration of a sample liquid analyzed by the analyzer, R is the response actually measured in the analyzer or a cubic spline function of that response, K is a coefficient assigned to the analyzer, and a0, a1 and a2 are said calibration coefficients which can vary beyond that which can be specified using (10n) digits;
the method comprising the steps of;a) ascertaining by statistical analysis the ranges of values for R that are possible for three given concentration values C1, C2 and C3, for a given assay, and assigning a high value H and a low value L for these ranges; b) calculating for a given lot of the given assay, a calibration curve that correlates the analyzer response to the concentration; c) determining the analyzer response R1, R2 and R3 from said calibration curve, that corresponds to said C1, C2 and C3 values; d) calculating the bar code value Bi for Ri of each of these R1, R2 and R3 from the equation
space="preserve" listing-type="equation">B.sub.i =(10.sup.n -1)(R.sub.i -L.sub.i)/(H.sub.i -L.sub.i)(2)where Ri is R1, R2 or R3, and Li and Hi are the corresponding L and H values for that Ri ; e) rounding Bi to the nearest integer; and f) supplying this value of Bi for each of Ri =R1, R2 or R3 in bar code form, so that only three sets of (10n) possibilities are needed to accurately pass along data corresponding to said calibration coefficients even though each of said three coefficients can vary by more than that which can be specified using 10n digits. - View Dependent Claims (2, 3)
- space="preserve" listing-type="equation">C=a.sub.0 +a.sub.1 ·
Specification
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- Resources
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Current AssigneeClinical Diagnostic Systems Inc.
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Original AssigneeEastman Kodak Company
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InventorsKildal-Brandt, Paul A., Weber, Thomas A.
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Primary Examiner(s)Lall, Parshotam S.
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Assistant Examiner(s)MELNICK, STEVEN A
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Application NumberUS07/644,058Time in Patent Office525 DaysField of Search364/571.01, 364/571.02, 364/571.03, 364/571.04, 364/571.05, 364/571.06, 364/571.07, 364/571.08, 364/556, 364/550, 364/554, 364/525, 235/462US Class Current702/91CPC Class CodesG01N 33/48771 Coding of information, e.g....
