Fiber-optic physiological probes
First Claim
1. A fiber optic sensor suitable for monitoring physiological analyte concentration, comprising a preformed film of an analyte permeable matrix disposed in a light path defined by an axial core at one end of an optical fiber segment, the analyte permeable matrix comprising an indicator molecule covalently linked to or admixed with a polymer, the indicator molecule capable of responding to the analyte in an optically-detectable manner.
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Abstract
Fiber optic sensors suitable for monitoring physiological analyte concentrations are described. The sensors include analyte permeable matrices disposed in a light path defined by the axial core at one end of an optical fiber segment. The matrix contains an indicator molecule covalently linked to a polymer or admixed with the polymer. The indicator molecule may be an absorptive molecule or a luminescent molecule. pH, PCO2, and PO2 sensors are described and may be disposed together in substantially coterminal arrangement to make a multivariable probe.
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Citations
20 Claims
- 1. A fiber optic sensor suitable for monitoring physiological analyte concentration, comprising a preformed film of an analyte permeable matrix disposed in a light path defined by an axial core at one end of an optical fiber segment, the analyte permeable matrix comprising an indicator molecule covalently linked to or admixed with a polymer, the indicator molecule capable of responding to the analyte in an optically-detectable manner.
Specification