Dosage form for Parkinson's disease, spasticity and muscle spasms
First Claim
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1. A dosage form for delivering a drug to a drug receptor, wherein the dosage form comprises:
- (a) a wall comprising at least in part a composition permeable to the passage of fluid, which wall surrounds;
(b) a compartment;
(c) at least one exit port in the wall that connects the exterior of the dosage form with the compartment;
(d) a dispensing composition in the compartment comprising a maltodextrin comprising a 500 to 1,000,000 molecular weight and a degree of polymerization of 3 to 6,140;
(e) 1 mg to 750 mg of drug in the dispensing composition for delivering the drug, by the combined operations of (a) and (b), through the exit port from the dosage form; and
,(f) a push composition in the compartment comprising a hydrogel and an osmotically effective solute, which composition in the presence of fluid that enters the compartment increases in volume and thereby pushes the dispensing composition from the dosage form.
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Abstract
A dosage form is disclosed comprising a drug and a maltodextrin polymer for administering to a patient a drug in need of therapy.
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Citations
4 Claims
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1. A dosage form for delivering a drug to a drug receptor, wherein the dosage form comprises:
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(a) a wall comprising at least in part a composition permeable to the passage of fluid, which wall surrounds; (b) a compartment; (c) at least one exit port in the wall that connects the exterior of the dosage form with the compartment; (d) a dispensing composition in the compartment comprising a maltodextrin comprising a 500 to 1,000,000 molecular weight and a degree of polymerization of 3 to 6,140; (e) 1 mg to 750 mg of drug in the dispensing composition for delivering the drug, by the combined operations of (a) and (b), through the exit port from the dosage form; and
,(f) a push composition in the compartment comprising a hydrogel and an osmotically effective solute, which composition in the presence of fluid that enters the compartment increases in volume and thereby pushes the dispensing composition from the dosage form. - View Dependent Claims (2, 3)
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4. An improvement in an osmotic dosage form for delivering a drug to a patient, wherein the osmotic dosage form comprises:
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(a) a wall comprising a composition permeable to the passage of fluid, which wall surrounds; (b) a compartment; (c) at least one passageway in the wall that connects the exterior of the osmotic dosage form with the compartment; (d) a composition in the compartment that increases its volume in the presence of fluid that enters the compartment; (e) a dose of a drug in the compartment; (f) a dose of a drug in contact with the exterior of the osmotic dosage form; and
wherein the improvement comprises;(g) a maltodextrin in the compartment comprising a 500 to 1,000,000 molecular weight and a degree of polymerization of 3 to 6,140, which maltodextrin is compatible with the drug and aids in delivering the drug through the passageway from the osmotic dosage form.
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Specification