Heat intensifier and localizer for radiofrequency thermotherapy

• US 5,128,147 A
• Filed: 08/06/1990
• Issued: 07/07/1992
• Est. Priority Date: 01/06/1989
• Status: Expired due to Fees

• Current Assignee: Thermal Developments Incorporated
• Original Assignee: Thermal Developments Incorporated
• Inventors: Leveen, Harry H., Leveen, Robert F., Leveen, Eric G.
• Primary Examiner(s): Waddell, Frederick E.
• Assistant Examiner(s): Gardner, Diane
• Application Number:
  US07/563,206
• Time in Patent Office: 701 Days
• Field of Search: 514/4, 424/497, 424/639, 424/641, 424/643, 424/646
• US Class Current: 424/497
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097

Abstract

A sterile injectable mixture which intensifies and localizes radio frequency thermotherapy; the injectable mixture contains finely ground ferrite particles in a viscid aqueous suspension, the ferrite being matched for maximum radio frequency absorption at a specific frequency. A chemotherapeutic agent, a surfactant and a bioacceptable hydrophic colloid are also contained in the mixture.

Claims

1. A sterile injectable mixture for injection into a tumor which intensifies and localizes radio frequency thermotherapy of the tumor, said mixture comprising the combination of finely ground manganese zinc ferrite means in an aqueous suspension, a surfactant, a chemotheraputic agent, an anesthetic agent and a thickening agent, said manganese zinc ferrite means comprising individual manganese and zinc complexed ferrite particles coated by microencapsulation with an inert plastic para-di-zylene.

2. A sterile injectable mixture as claimed in claim 1 wherein said aqueous suspension is in a saline solution.

3. A sterile injectable mixture as claimed in claim 1 wherein said aqueous suspension is a bioacceptable hydrophillic colloid.

4. A sterile injectable mixture as claimed in claim 3 wherein said hydrophillic colloid is sodium alginate.

5. A sterile injectable mixture as claimed in claim 3 wherein said hydrophillic colloid is dextran.

6. A sterile injectable mixture as claimed in claim 3 wherein said hydrophillic colloid is carbowax.

7. A sterile injectable mixture as claimed in claim 1 wherein said surfactant is lecithin.

8. A sterile injectable mixture as claimed in claim 1 wherein said surfactant is a non ionic detergent.

9. A sterile injectable mixture as claimed in claim 1 wherein said surfactant is a hydroxycellulose.

10. A sterile injectable mixture as claimed in claim 1 wherein said anesthetic agent is lidocaine.

11. A sterile injectable mixture as claimed in claim 1 wherein said anesthetic agent is porcaine.

12. A sterile injectable mixture for injection into a tumor which intensifies and localizes radio frequency thermotherapy, said mixture containing finely ground complexed manganese zinc ferrite particles in powder form, said complexed manganese zinc ferrite particles being at least two thirds iron and encapsulated in biologically inert plastic material in a viscid aqueous suspension, said complexed manganeses zinc ferrite particles being matched for maximum radio frequency absorption ranging from 13.56 mHz to about 27.12 mHz and substantially totally absorbing the energy of the radio frequency waves, said mixture further containing a chemotherapeutic agent, a surfactant and a bioacceptable hydrophillic colloid.